Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes
Background: Heart rate variability (HRV) represents changes in the time between successive heart beats, and it has been used to assess the autonomic nervous system. Previous studies have reported autonomic dysfunction in diabetic patients undergoing hemodialysis (HD), however, no studies have evalua...
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Frontiers Media S.A.
2018-02-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00043/full |
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English |
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DOAJ |
author |
Sheng-Wen Niu Sheng-Wen Niu Sheng-Wen Niu Jiun-Chi Huang Jiun-Chi Huang Jiun-Chi Huang Jiun-Chi Huang Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Hugo Y.-H. Lin Hugo Y.-H. Lin Hugo Y.-H. Lin Hugo Y.-H. Lin I.-Ching Kuo I.-Ching Kuo I.-Ching Kuo Pei-Yu Wu Pei-Yu Wu Yi-Wen Chiu Yi-Wen Chiu Jer-Ming Chang Jer-Ming Chang Jer-Ming Chang |
spellingShingle |
Sheng-Wen Niu Sheng-Wen Niu Sheng-Wen Niu Jiun-Chi Huang Jiun-Chi Huang Jiun-Chi Huang Jiun-Chi Huang Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Hugo Y.-H. Lin Hugo Y.-H. Lin Hugo Y.-H. Lin Hugo Y.-H. Lin I.-Ching Kuo I.-Ching Kuo I.-Ching Kuo Pei-Yu Wu Pei-Yu Wu Yi-Wen Chiu Yi-Wen Chiu Jer-Ming Chang Jer-Ming Chang Jer-Ming Chang Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes Frontiers in Aging Neuroscience heart rate variability autonomic nervous system age diabetes hemodialysis |
author_facet |
Sheng-Wen Niu Sheng-Wen Niu Sheng-Wen Niu Jiun-Chi Huang Jiun-Chi Huang Jiun-Chi Huang Jiun-Chi Huang Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Hugo Y.-H. Lin Hugo Y.-H. Lin Hugo Y.-H. Lin Hugo Y.-H. Lin I.-Ching Kuo I.-Ching Kuo I.-Ching Kuo Pei-Yu Wu Pei-Yu Wu Yi-Wen Chiu Yi-Wen Chiu Jer-Ming Chang Jer-Ming Chang Jer-Ming Chang |
author_sort |
Sheng-Wen Niu |
title |
Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes |
title_short |
Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes |
title_full |
Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes |
title_fullStr |
Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes |
title_full_unstemmed |
Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with Diabetes |
title_sort |
association between age and changes in heart rate variability after hemodialysis in patients with diabetes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2018-02-01 |
description |
Background: Heart rate variability (HRV) represents changes in the time between successive heart beats, and it has been used to assess the autonomic nervous system. Previous studies have reported autonomic dysfunction in diabetic patients undergoing hemodialysis (HD), however, no studies have evaluated the effects of age on changes in HRV in these patients. The aim of this study was to examine the effects of age on changes in HRV in diabetic HD patients.Methods: We enrolled 84 diabetic patients receiving maintenance HD. HRV was measured before and after HD to assess changes in HRV (ΔHRV). The patients were divided into two groups based on their age (65 years< or ≥65 years).Results: Compared to the patients aged <65 years, those aged ≥65 years had a higher high frequency (HF) % (p = 0.032) before HD. The patients aged <65 years had a significant increase in very low frequency, low frequency (LF), and HF after HD. The patients aged ≥65 years had a significant increase in LF, but a significant decrease in HF% after HD. There was a significant interaction between age and change of HF% (p = 0.023) after HD. After multivariate adjustments for clinical, biochemical data and medications, systolic blood pressure, total cholesterol, hemoglobin, and hemoglobin were associated with ΔLF, whereas cerebrovascular disease, systolic blood pressure, and fasting glucose were associated with ΔHF% in patients aged ≥65 years.Conclusion: Our study demonstrated significant changes in HRV after HD in diabetic patients. In the patients aged ≥65 years, LF was increased, whereas HF% was decreased significantly after HD. Among the HRV parameters, age had an interaction with the change of HF%. |
topic |
heart rate variability autonomic nervous system age diabetes hemodialysis |
url |
http://journal.frontiersin.org/article/10.3389/fnagi.2018.00043/full |
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doaj-d636805e00744f519063fafb1ef9ff512020-11-24T22:35:01ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-02-011010.3389/fnagi.2018.00043339030Association between Age and Changes in Heart Rate Variability after Hemodialysis in Patients with DiabetesSheng-Wen Niu0Sheng-Wen Niu1Sheng-Wen Niu2Jiun-Chi Huang3Jiun-Chi Huang4Jiun-Chi Huang5Jiun-Chi Huang6Szu-Chia Chen7Szu-Chia Chen8Szu-Chia Chen9Szu-Chia Chen10Hugo Y.-H. Lin11Hugo Y.-H. Lin12Hugo Y.-H. Lin13Hugo Y.-H. Lin14I.-Ching Kuo15I.-Ching Kuo16I.-Ching Kuo17Pei-Yu Wu18Pei-Yu Wu19Yi-Wen Chiu20Yi-Wen Chiu21Jer-Ming Chang22Jer-Ming Chang23Jer-Ming Chang24Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Cijin Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanBackground: Heart rate variability (HRV) represents changes in the time between successive heart beats, and it has been used to assess the autonomic nervous system. Previous studies have reported autonomic dysfunction in diabetic patients undergoing hemodialysis (HD), however, no studies have evaluated the effects of age on changes in HRV in these patients. The aim of this study was to examine the effects of age on changes in HRV in diabetic HD patients.Methods: We enrolled 84 diabetic patients receiving maintenance HD. HRV was measured before and after HD to assess changes in HRV (ΔHRV). The patients were divided into two groups based on their age (65 years< or ≥65 years).Results: Compared to the patients aged <65 years, those aged ≥65 years had a higher high frequency (HF) % (p = 0.032) before HD. The patients aged <65 years had a significant increase in very low frequency, low frequency (LF), and HF after HD. The patients aged ≥65 years had a significant increase in LF, but a significant decrease in HF% after HD. There was a significant interaction between age and change of HF% (p = 0.023) after HD. After multivariate adjustments for clinical, biochemical data and medications, systolic blood pressure, total cholesterol, hemoglobin, and hemoglobin were associated with ΔLF, whereas cerebrovascular disease, systolic blood pressure, and fasting glucose were associated with ΔHF% in patients aged ≥65 years.Conclusion: Our study demonstrated significant changes in HRV after HD in diabetic patients. In the patients aged ≥65 years, LF was increased, whereas HF% was decreased significantly after HD. Among the HRV parameters, age had an interaction with the change of HF%.http://journal.frontiersin.org/article/10.3389/fnagi.2018.00043/fullheart rate variabilityautonomic nervous systemagediabeteshemodialysis |