Cooperative inhibition of RIP1-mediated NF-κB signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit.
Several viruses have been found to encode a deubiquitinating protease (DUB). These viral DUBs are proposed to play a role in regulating innate immune or inflammatory signaling. In human cytomegalovirus (HCMV), the largest tegument protein encoded by UL48 contains DUB activity, but its cellular targe...
Main Authors: | Ki Mun Kwon, Se Eun Oh, Young Eui Kim, Tae-Hee Han, Jin-Hyun Ahn |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-06-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5469499?pdf=render |
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