Sulfatide regulates caspase-3-independent apoptosis of influenza A virus through viral PB1-F2 protein.
Influenza A virus (IAV) generally causes caspase-dependent apoptosis based on caspase-3 activation, resulting in nuclear export of newly synthesized viral nucleoprotein (NP) and elevated virus replication. Sulfatide, a sulfated galactosylsphingolipid, enhances IAV replication through promoting newly...
Main Authors: | Tadanobu Takahashi, Masahiro Takaguchi, Tatsuya Kawakami, Takashi Suzuki |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3617187?pdf=render |
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