Interaction of Psoriasis and Bullous Diseases
Patients with psoriasis are frequently complicated with autoimmune bullous diseases, especially, pemphigoid diseases. It has been known that one-third cases of anti-laminin gamma1 pemphigoid, formerly anti-p200 pemphigoid, are associated with psoriasis whereas bullous pemphigoid is the most frequent...
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2018-08-01
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doaj-d64b19734f0145ee8dd8328973f2dfc42020-11-24T21:40:51ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-08-01510.3389/fmed.2018.00222400935Interaction of Psoriasis and Bullous DiseasesTeruki Dainichi0Kenji Kabashima1Kenji Kabashima2Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, JapanSingapore Immunology Network and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore, SingaporePatients with psoriasis are frequently complicated with autoimmune bullous diseases, especially, pemphigoid diseases. It has been known that one-third cases of anti-laminin gamma1 pemphigoid, formerly anti-p200 pemphigoid, are associated with psoriasis whereas bullous pemphigoid is the most frequently associated bullous disease in psoriasis cases regardless of the lack of detectable levels of the accompanying anti-laminin gamma1 autoantibodies. Despite several suggestions, however, the definitive reason of the striking association of psoriasis and these autoimmune bullous diseases remains elusive. In this review, we look over the epidemiological evidence of the association of psoriasis and autoimmune bullous diseases and the information of genetic susceptibilities of each disease, and discuss the possible mechanisms of their complication with reference to the recent understandings of each pathogenesis.https://www.frontiersin.org/article/10.3389/fmed.2018.00222/fullautoimmunityTh2Th17psoriasispemphigoidlaminin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teruki Dainichi Kenji Kabashima Kenji Kabashima |
spellingShingle |
Teruki Dainichi Kenji Kabashima Kenji Kabashima Interaction of Psoriasis and Bullous Diseases Frontiers in Medicine autoimmunity Th2 Th17 psoriasis pemphigoid laminin |
author_facet |
Teruki Dainichi Kenji Kabashima Kenji Kabashima |
author_sort |
Teruki Dainichi |
title |
Interaction of Psoriasis and Bullous Diseases |
title_short |
Interaction of Psoriasis and Bullous Diseases |
title_full |
Interaction of Psoriasis and Bullous Diseases |
title_fullStr |
Interaction of Psoriasis and Bullous Diseases |
title_full_unstemmed |
Interaction of Psoriasis and Bullous Diseases |
title_sort |
interaction of psoriasis and bullous diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2018-08-01 |
description |
Patients with psoriasis are frequently complicated with autoimmune bullous diseases, especially, pemphigoid diseases. It has been known that one-third cases of anti-laminin gamma1 pemphigoid, formerly anti-p200 pemphigoid, are associated with psoriasis whereas bullous pemphigoid is the most frequently associated bullous disease in psoriasis cases regardless of the lack of detectable levels of the accompanying anti-laminin gamma1 autoantibodies. Despite several suggestions, however, the definitive reason of the striking association of psoriasis and these autoimmune bullous diseases remains elusive. In this review, we look over the epidemiological evidence of the association of psoriasis and autoimmune bullous diseases and the information of genetic susceptibilities of each disease, and discuss the possible mechanisms of their complication with reference to the recent understandings of each pathogenesis. |
topic |
autoimmunity Th2 Th17 psoriasis pemphigoid laminin |
url |
https://www.frontiersin.org/article/10.3389/fmed.2018.00222/full |
work_keys_str_mv |
AT terukidainichi interactionofpsoriasisandbullousdiseases AT kenjikabashima interactionofpsoriasisandbullousdiseases AT kenjikabashima interactionofpsoriasisandbullousdiseases |
_version_ |
1725924340240744448 |