Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th...
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Bibliographic Details
Main Authors: |
Kerry L. Hilligan,
Shiau-Choot Tang,
Evelyn J. Hyde,
Elsa Roussel,
Johannes U. Mayer,
Jianping Yang,
Kirsty A. Wakelin,
Alfonso J. Schmidt,
Lisa M. Connor,
Alan Sher,
Andrew S. MacDonald,
Franca Ronchese |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2020-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-020-19463-9
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