Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th...

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Main Authors:	Kerry L. Hilligan, Shiau-Choot Tang, Evelyn J. Hyde, Elsa Roussel, Johannes U. Mayer, Jianping Yang, Kirsty A. Wakelin, Alfonso J. Schmidt, Lisa M. Connor, Alan Sher, Andrew S. MacDonald, Franca Ronchese
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19463-9

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spelling	doaj-d65f3d80f398424cae180d6d1bb01a612021-05-11T08:55:49ZengNature Publishing GroupNature Communications2041-17232020-11-0111111410.1038/s41467-020-19463-9Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profilesKerry L. Hilligan0Shiau-Choot Tang1Evelyn J. Hyde2Elsa Roussel3Johannes U. Mayer4Jianping Yang5Kirsty A. Wakelin6Alfonso J. Schmidt7Lisa M. Connor8Alan Sher9Andrew S. MacDonald10Franca Ronchese11Malaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchMalaghan Institute of Medical ResearchImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science CentreMalaghan Institute of Medical ResearchAntigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th17 responses following skin inoculation.https://doi.org/10.1038/s41467-020-19463-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kerry L. Hilligan Shiau-Choot Tang Evelyn J. Hyde Elsa Roussel Johannes U. Mayer Jianping Yang Kirsty A. Wakelin Alfonso J. Schmidt Lisa M. Connor Alan Sher Andrew S. MacDonald Franca Ronchese
spellingShingle	Kerry L. Hilligan Shiau-Choot Tang Evelyn J. Hyde Elsa Roussel Johannes U. Mayer Jianping Yang Kirsty A. Wakelin Alfonso J. Schmidt Lisa M. Connor Alan Sher Andrew S. MacDonald Franca Ronchese Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles Nature Communications
author_facet	Kerry L. Hilligan Shiau-Choot Tang Evelyn J. Hyde Elsa Roussel Johannes U. Mayer Jianping Yang Kirsty A. Wakelin Alfonso J. Schmidt Lisa M. Connor Alan Sher Andrew S. MacDonald Franca Ronchese
author_sort	Kerry L. Hilligan
title	Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
title_short	Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
title_full	Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
title_fullStr	Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
title_full_unstemmed	Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
title_sort	dermal irf4+ dendritic cells and monocytes license cd4+ t helper cells to distinct cytokine profiles
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-11-01
description	Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th17 responses following skin inoculation.
url	https://doi.org/10.1038/s41467-020-19463-9
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Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

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