Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo
The investigation of traditionally used medicinal plants is valuable both as a source of potential chemotherapeutic drugs and as a measure of safety for the continued use of these medicinal plants. Achillea millefolium L. (AM) is an ancient remedial herb native to Europe that is used to treat wounds...
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doaj-d66124e4f60d44d7a66aca9f7822a90d2020-11-24T22:26:37ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/893050893050Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In VivoElisângela Düsman0Igor Vivian de Almeida1Ana Carolina Coelho2Thiago José Balbi3Lilian Tatiani Düsman Tonin4Veronica Elisa Pimenta Vicentini5Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, 87020-900 Maringá, PR, BrazilDepartment of Biotechnology, Genetics and Cell Biology, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, 87020-900 Maringá, PR, BrazilDepartment of Biotechnology, Genetics and Cell Biology, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, 87020-900 Maringá, PR, BrazilDepartment of Biotechnology, Genetics and Cell Biology, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, 87020-900 Maringá, PR, BrazilFederal Technological University of Paraná, Rua Marcílio Dias 635, 86812-460 Apucarana, PR, BrazilDepartment of Biotechnology, Genetics and Cell Biology, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, 87020-900 Maringá, PR, BrazilThe investigation of traditionally used medicinal plants is valuable both as a source of potential chemotherapeutic drugs and as a measure of safety for the continued use of these medicinal plants. Achillea millefolium L. (AM) is an ancient remedial herb native to Europe that is used to treat wounds, gastrointestinal and hepatobiliary disorders, inflammation, headaches, and pain. Bauhinia forficata Link (BF), an Asiatic plant, is one of the most commonly used plants in folk medicine against diabetes. The aim of this study was to evaluate the cytotoxic and antimutagenic potential of aqueous extracts of AM and BF on bone marrow cells of Wistar rats treated in vivo. These plant extracts possess considerable antioxidant activity due to the presence of flavonoids and phenolic compounds. These compounds were determinants to noncytotoxic and antimutagenic/protective action of these plants, that reduced statistically the percentage of chromosomal alterations induced by the chemotherapeutic agent cyclophosphamide in simultaneous (AM, 68%; BF, 91%), pre- (AM, 68%; BF, 71%), and post-treatment (AM, 67%; BF, 95%). Therefore, the results of this study indicate that extracts of A. millefolium and B. forficata have antimutagenic potential and that their consumption can benefit the health of those using them as an alternative therapy.http://dx.doi.org/10.1155/2013/893050 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisângela Düsman Igor Vivian de Almeida Ana Carolina Coelho Thiago José Balbi Lilian Tatiani Düsman Tonin Veronica Elisa Pimenta Vicentini |
spellingShingle |
Elisângela Düsman Igor Vivian de Almeida Ana Carolina Coelho Thiago José Balbi Lilian Tatiani Düsman Tonin Veronica Elisa Pimenta Vicentini Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo Evidence-Based Complementary and Alternative Medicine |
author_facet |
Elisângela Düsman Igor Vivian de Almeida Ana Carolina Coelho Thiago José Balbi Lilian Tatiani Düsman Tonin Veronica Elisa Pimenta Vicentini |
author_sort |
Elisângela Düsman |
title |
Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo |
title_short |
Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo |
title_full |
Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo |
title_fullStr |
Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo |
title_full_unstemmed |
Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo |
title_sort |
antimutagenic effect of medicinal plants achillea millefolium and bauhinia forficata in vivo |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
The investigation of traditionally used medicinal plants is valuable both as a source of potential chemotherapeutic drugs and as a measure of safety for the continued use of these medicinal plants. Achillea millefolium L. (AM) is an ancient remedial herb native to Europe that is used to treat wounds, gastrointestinal and hepatobiliary disorders, inflammation, headaches, and pain. Bauhinia forficata Link (BF), an Asiatic plant, is one of the most commonly used plants in folk medicine against diabetes. The aim of this study was to evaluate the cytotoxic and antimutagenic potential of aqueous extracts of AM and BF on bone marrow cells of Wistar rats treated in vivo. These plant extracts possess considerable antioxidant activity due to the presence of flavonoids and phenolic compounds. These compounds were determinants to noncytotoxic and antimutagenic/protective action of these plants, that reduced statistically the percentage of chromosomal alterations induced by the chemotherapeutic agent cyclophosphamide in simultaneous (AM, 68%; BF, 91%), pre- (AM, 68%; BF, 71%), and post-treatment (AM, 67%; BF, 95%). Therefore, the results of this study indicate that extracts of A. millefolium and B. forficata have antimutagenic potential and that their consumption can benefit the health of those using them as an alternative therapy. |
url |
http://dx.doi.org/10.1155/2013/893050 |
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