TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke
Background: Stroke affects the neuronal networks of the non-infarcted hemisphere. The central motor conduction time (CMCT) induced by transcranial magnetic stimulation (TMS) could be used to determine the conduction time of the corticospinal tract of the non-infarcted hemisphere after a stroke. Obje...
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doaj-d66c3bd229834ebb98b961a43c5369532021-06-01T00:09:50ZengMDPI AGBrain Sciences2076-34252021-05-011164864810.3390/brainsci11050648TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe StrokeMaurits H. J. Hoonhorst0Rinske H. M. Nijland1Cornelis H. Emmelot2Boudewijn J. Kollen3Gert Kwakkel4Rehabilitation Center Vogellanden, 8013 XZ Zwolle, The NetherlandsAmsterdam Rehabilitation Research Center|Reade, 1054 HW Amsterdam, The NetherlandsDepartment of Rehabilitation Medicine, Isala, 8025 AB Zwolle, The NetherlandsDepartment of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, 9712 CP Groningen, The NetherlandsAmsterdam Rehabilitation Research Center|Reade, 1054 HW Amsterdam, The NetherlandsBackground: Stroke affects the neuronal networks of the non-infarcted hemisphere. The central motor conduction time (CMCT) induced by transcranial magnetic stimulation (TMS) could be used to determine the conduction time of the corticospinal tract of the non-infarcted hemisphere after a stroke. Objectives: Our primary aim was to demonstrate the existence of prolonged CMCT in the non-infarcted hemisphere, measured within the first 48 h when compared to normative data, and secondly, if the severity of motor impairment of the affected upper limb was significantly associated with prolonged CMCTs in the non-infarcted hemisphere when measured within the first 2 weeks post stroke. Methods: CMCT in the non-infarcted hemisphere was measured in 50 patients within 48 h and at 11 days after a first-ever ischemic stroke. Patients lacking significant spontaneous motor recovery, so-called non-recoverers, were defined as those who started below 18 points on the FM-UE and showed less than 6 points (10%) improvement within 6 months. Results: CMCT in the non-infarcted hemisphere was prolonged in 30/50 (60%) patients within 48 h and still in 24/49 (49%) patients at 11 days. Sustained prolonged CMCT in the non-infarcted hemisphere was significantly more frequent in non-recoverers following FM-UE. Conclusions: The current study suggests that CMCT in the non-infarcted hemisphere is significantly prolonged in 60% of severely affected, ischemic stroke patients when measured within the first 48 h post stroke. The likelihood of CMCT is significantly higher in non-recoverers when compared to those that show spontaneous motor recovery early post stroke.https://www.mdpi.com/2076-3425/11/5/648strokerecoveryupper limbprognosistranscranial magnetic stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maurits H. J. Hoonhorst Rinske H. M. Nijland Cornelis H. Emmelot Boudewijn J. Kollen Gert Kwakkel |
spellingShingle |
Maurits H. J. Hoonhorst Rinske H. M. Nijland Cornelis H. Emmelot Boudewijn J. Kollen Gert Kwakkel TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke Brain Sciences stroke recovery upper limb prognosis transcranial magnetic stimulation |
author_facet |
Maurits H. J. Hoonhorst Rinske H. M. Nijland Cornelis H. Emmelot Boudewijn J. Kollen Gert Kwakkel |
author_sort |
Maurits H. J. Hoonhorst |
title |
TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke |
title_short |
TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke |
title_full |
TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke |
title_fullStr |
TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke |
title_full_unstemmed |
TMS-Induced Central Motor Conduction Time at the Non-Infarcted Hemisphere Is Associated with Spontaneous Motor Recovery of the Paretic Upper Limb after Severe Stroke |
title_sort |
tms-induced central motor conduction time at the non-infarcted hemisphere is associated with spontaneous motor recovery of the paretic upper limb after severe stroke |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-05-01 |
description |
Background: Stroke affects the neuronal networks of the non-infarcted hemisphere. The central motor conduction time (CMCT) induced by transcranial magnetic stimulation (TMS) could be used to determine the conduction time of the corticospinal tract of the non-infarcted hemisphere after a stroke. Objectives: Our primary aim was to demonstrate the existence of prolonged CMCT in the non-infarcted hemisphere, measured within the first 48 h when compared to normative data, and secondly, if the severity of motor impairment of the affected upper limb was significantly associated with prolonged CMCTs in the non-infarcted hemisphere when measured within the first 2 weeks post stroke. Methods: CMCT in the non-infarcted hemisphere was measured in 50 patients within 48 h and at 11 days after a first-ever ischemic stroke. Patients lacking significant spontaneous motor recovery, so-called non-recoverers, were defined as those who started below 18 points on the FM-UE and showed less than 6 points (10%) improvement within 6 months. Results: CMCT in the non-infarcted hemisphere was prolonged in 30/50 (60%) patients within 48 h and still in 24/49 (49%) patients at 11 days. Sustained prolonged CMCT in the non-infarcted hemisphere was significantly more frequent in non-recoverers following FM-UE. Conclusions: The current study suggests that CMCT in the non-infarcted hemisphere is significantly prolonged in 60% of severely affected, ischemic stroke patients when measured within the first 48 h post stroke. The likelihood of CMCT is significantly higher in non-recoverers when compared to those that show spontaneous motor recovery early post stroke. |
topic |
stroke recovery upper limb prognosis transcranial magnetic stimulation |
url |
https://www.mdpi.com/2076-3425/11/5/648 |
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