Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis

Toxoplasma gondii is a known cause of encephalitis in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Toxoplasma pneumonitis is a manifestation of extracerebral toxoplasmosis and can be clinically indistinguishable from other opportunistic infections including Pn...

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Main Authors:	Moni Roy, Nikhut Siddique, Bindu Bathina, Sharjeel Ahmad
Format:	Article
Language:	English
Published:	SMC MEDIA SRL 2020-09-01
Series:	European Journal of Case Reports in Internal Medicine
Subjects:	disseminated toxoplasmosis toxoplasma pneumonitis next-generation sequencing hiv/aids
Online Access:	https://www.ejcrim.com/index.php/EJCRIM/article/view/1862

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spelling	doaj-d66fe2e5b245415fae3bc96bf0cb805b2020-11-25T02:53:00ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942020-09-0110.12890/2020_0018621482Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for DiagnosisMoni Roy0Nikhut Siddique1Bindu Bathina2Sharjeel Ahmad3Department of Internal Medicine, University of Illinois College of Medicine, Peoria, Illinois AND OSF Saint Francis Medical Center, Peoria, Illinois Department of Internal Medicine, University of Illinois College of Medicine, Peoria, Illinois, USADepartment of Internal Medicine, University of Illinois College of Medicine, Peoria, Illinois AND OSF Saint Francis Medical Center, Peoria, IllinoisDepartment of Internal Medicine, Section of Infectious Diseases, University of Illinois College of Medicine, Peoria, Illinois, USAToxoplasma gondii is a known cause of encephalitis in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Toxoplasma pneumonitis is a manifestation of extracerebral toxoplasmosis and can be clinically indistinguishable from other opportunistic infections including Pneumocystis jirovecii pneumonia (PJP) and miliary tuberculosis. In this case report, Toxoplasma pneumonitis and disseminated toxoplasmosis was diagnosed using next-generation sequencing (NGS) and polymerase chain reaction (PCR) assessment. NGS can detect microbial cell-free DNA (cfDNA) circulating in the plasma of over 1,000 pathogens. This case is a rare presentation of Toxoplasma pneumonitis in the absence of neurological symptoms and we discuss the use of NGS of microbial cfDNA and PCR tests that may be utilized for the timely diagnosis of such challenging cases.https://www.ejcrim.com/index.php/EJCRIM/article/view/1862disseminated toxoplasmosistoxoplasma pneumonitisnext-generation sequencing hiv/aids
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Moni Roy Nikhut Siddique Bindu Bathina Sharjeel Ahmad
spellingShingle	Moni Roy Nikhut Siddique Bindu Bathina Sharjeel Ahmad Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis European Journal of Case Reports in Internal Medicine disseminated toxoplasmosis toxoplasma pneumonitis next-generation sequencing hiv/aids
author_facet	Moni Roy Nikhut Siddique Bindu Bathina Sharjeel Ahmad
author_sort	Moni Roy
title	Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis
title_short	Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis
title_full	Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis
title_fullStr	Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis
title_full_unstemmed	Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis
title_sort	rare presentation of toxoplasma pneumonitis in the absence of neurological symptoms in an aids patient and use of next-generation sequencing for diagnosis
publisher	SMC MEDIA SRL
series	European Journal of Case Reports in Internal Medicine
issn	2284-2594
publishDate	2020-09-01
description	Toxoplasma gondii is a known cause of encephalitis in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Toxoplasma pneumonitis is a manifestation of extracerebral toxoplasmosis and can be clinically indistinguishable from other opportunistic infections including Pneumocystis jirovecii pneumonia (PJP) and miliary tuberculosis. In this case report, Toxoplasma pneumonitis and disseminated toxoplasmosis was diagnosed using next-generation sequencing (NGS) and polymerase chain reaction (PCR) assessment. NGS can detect microbial cell-free DNA (cfDNA) circulating in the plasma of over 1,000 pathogens. This case is a rare presentation of Toxoplasma pneumonitis in the absence of neurological symptoms and we discuss the use of NGS of microbial cfDNA and PCR tests that may be utilized for the timely diagnosis of such challenging cases.
topic	disseminated toxoplasmosis toxoplasma pneumonitis next-generation sequencing hiv/aids
url	https://www.ejcrim.com/index.php/EJCRIM/article/view/1862
work_keys_str_mv	AT moniroy rarepresentationoftoxoplasmapneumonitisintheabsenceofneurologicalsymptomsinanaidspatientanduseofnextgenerationsequencingfordiagnosis AT nikhutsiddique rarepresentationoftoxoplasmapneumonitisintheabsenceofneurologicalsymptomsinanaidspatientanduseofnextgenerationsequencingfordiagnosis AT bindubathina rarepresentationoftoxoplasmapneumonitisintheabsenceofneurologicalsymptomsinanaidspatientanduseofnextgenerationsequencingfordiagnosis AT sharjeelahmad rarepresentationoftoxoplasmapneumonitisintheabsenceofneurologicalsymptomsinanaidspatientanduseofnextgenerationsequencingfordiagnosis
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Rare Presentation of Toxoplasma Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis

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