Gene Expression and Regulation in Adrenocortical Tumorigenesis
Adrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the...
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doaj-d676bad5099c400a9daaaeaccbeccfbb2020-11-24T23:08:28ZengMDPI AGBiology2079-77372012-12-0121263910.3390/biology2010026Gene Expression and Regulation in Adrenocortical TumorigenesisTobias CarlingReju KorahJohn W. KunstmanAnnabelle L. FonsecaJames HealyAdrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the absence of widely invasive or metastatic disease, and hence attention has turned towards a search for molecular markers. The study of rare genetic diseases that are associated with the development of adrenocortical carcinomas has contributed to our understanding of adrenocortical tumorigenesis. In addition, comprehensive genomic hybridization, methylation profiling, and genome wide mRNA and miRNA profiling have led to improvements in our understanding, as well as demonstrated several genes and pathways that may serve as diagnostic or prognostic markers.http://www.mdpi.com/2079-7737/2/1/26adrenocortical tumorepigeneticsgene expressiongenetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tobias Carling Reju Korah John W. Kunstman Annabelle L. Fonseca James Healy |
spellingShingle |
Tobias Carling Reju Korah John W. Kunstman Annabelle L. Fonseca James Healy Gene Expression and Regulation in Adrenocortical Tumorigenesis Biology adrenocortical tumor epigenetics gene expression genetics |
author_facet |
Tobias Carling Reju Korah John W. Kunstman Annabelle L. Fonseca James Healy |
author_sort |
Tobias Carling |
title |
Gene Expression and Regulation in Adrenocortical Tumorigenesis |
title_short |
Gene Expression and Regulation in Adrenocortical Tumorigenesis |
title_full |
Gene Expression and Regulation in Adrenocortical Tumorigenesis |
title_fullStr |
Gene Expression and Regulation in Adrenocortical Tumorigenesis |
title_full_unstemmed |
Gene Expression and Regulation in Adrenocortical Tumorigenesis |
title_sort |
gene expression and regulation in adrenocortical tumorigenesis |
publisher |
MDPI AG |
series |
Biology |
issn |
2079-7737 |
publishDate |
2012-12-01 |
description |
Adrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the absence of widely invasive or metastatic disease, and hence attention has turned towards a search for molecular markers. The study of rare genetic diseases that are associated with the development of adrenocortical carcinomas has contributed to our understanding of adrenocortical tumorigenesis. In addition, comprehensive genomic hybridization, methylation profiling, and genome wide mRNA and miRNA profiling have led to improvements in our understanding, as well as demonstrated several genes and pathways that may serve as diagnostic or prognostic markers. |
topic |
adrenocortical tumor epigenetics gene expression genetics |
url |
http://www.mdpi.com/2079-7737/2/1/26 |
work_keys_str_mv |
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_version_ |
1725614118289801216 |