The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries

Background Neutrophil to lymphocyte ratio (NLR) is a simple marker in peripheral blood and is used to assess inflammatory response and physiological stress during the peri-operative period. Anesthetic technique may influence NLR, thereby modulating the inflammatory response and surgical outcomes. Th...

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Main Authors: Nethra Surhonne, Chaithali Hebri, Sudheesh Kannan, Devika Rani Duggappa, Raghavendra Rao RS, Chethana G Mapari
Format: Article
Language:English
Published: Korean Society of Anesthesiologists 2019-10-01
Series:Korean Journal of Anesthesiology
Subjects:
Online Access:http://ekja.org/upload/pdf/kja-d-19-00022.pdf
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spelling doaj-d67fe0d81c1d44adb024e61cb287551d2020-11-25T03:39:16ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632019-10-0172545846510.4097/kja.d.19.000228535The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeriesNethra Surhonne0Chaithali Hebri1Sudheesh KannanDevika Rani Duggappa2Raghavendra Rao RS3Chethana G Mapari4 Department of Anesthesiology, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India Department of Anesthesiology, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India Department of Anesthesiology, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India Department of Anesthesiology, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India Department of Anesthesiology, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, IndiaBackground Neutrophil to lymphocyte ratio (NLR) is a simple marker in peripheral blood and is used to assess inflammatory response and physiological stress during the peri-operative period. Anesthetic technique may influence NLR, thereby modulating the inflammatory response and surgical outcomes. The study aimed to evaluate the relationship between blood NLR and anesthetic techniques in patients undergoing infraumbilical surgeries. Methods Institutional ethical committee approval and patient consent were obtained. A prospective randomized double- blinded study was conducted between July 2017 and November 2017, involving 80 patients classified as the American Society of Anesthesiologists grade 1 and 2, aged 18–60 years, and scheduled for elective infraumbilical surgeries. Unwilling and those with infections were excluded. The patients were randomly divided into two groups: Group G (general anesthesia) and Group S (spinal anesthesia) as per the standardized protocol. Differential counts of leukocytes and NLR in the peripheral blood were obtained pre-operatively on the morning of surgery and at 2 h and 24 h after surgery in both the groups. The data were analyzed using appropriate statistical tests. Results The demographic parameters, basal total leukocyte count (TLC), and NLR were comparable between the groups. TLC and NLR were significantly higher in Group G as compared to that in Group S post-operatively. The post-operative rise in TLC and NLR from the basal values was significantly higher in Group G as compared to that in Group S. Conclusions General anesthesia was associated with a greater increase in TLC and NLR when compared with spinal anesthesia.http://ekja.org/upload/pdf/kja-d-19-00022.pdfgeneral anesthesialymphocytesneutrophilsneutrophil lymphocyte ratiospinal anesthesia
collection DOAJ
language English
format Article
sources DOAJ
author Nethra Surhonne
Chaithali Hebri
Sudheesh Kannan
Devika Rani Duggappa
Raghavendra Rao RS
Chethana G Mapari
spellingShingle Nethra Surhonne
Chaithali Hebri
Sudheesh Kannan
Devika Rani Duggappa
Raghavendra Rao RS
Chethana G Mapari
The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
Korean Journal of Anesthesiology
general anesthesia
lymphocytes
neutrophils
neutrophil lymphocyte ratio
spinal anesthesia
author_facet Nethra Surhonne
Chaithali Hebri
Sudheesh Kannan
Devika Rani Duggappa
Raghavendra Rao RS
Chethana G Mapari
author_sort Nethra Surhonne
title The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
title_short The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
title_full The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
title_fullStr The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
title_full_unstemmed The effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
title_sort effect of anesthetic techniques on neutrophil to lymphocyte ratio in patients undergoing infraumbilical surgeries
publisher Korean Society of Anesthesiologists
series Korean Journal of Anesthesiology
issn 2005-6419
2005-7563
publishDate 2019-10-01
description Background Neutrophil to lymphocyte ratio (NLR) is a simple marker in peripheral blood and is used to assess inflammatory response and physiological stress during the peri-operative period. Anesthetic technique may influence NLR, thereby modulating the inflammatory response and surgical outcomes. The study aimed to evaluate the relationship between blood NLR and anesthetic techniques in patients undergoing infraumbilical surgeries. Methods Institutional ethical committee approval and patient consent were obtained. A prospective randomized double- blinded study was conducted between July 2017 and November 2017, involving 80 patients classified as the American Society of Anesthesiologists grade 1 and 2, aged 18–60 years, and scheduled for elective infraumbilical surgeries. Unwilling and those with infections were excluded. The patients were randomly divided into two groups: Group G (general anesthesia) and Group S (spinal anesthesia) as per the standardized protocol. Differential counts of leukocytes and NLR in the peripheral blood were obtained pre-operatively on the morning of surgery and at 2 h and 24 h after surgery in both the groups. The data were analyzed using appropriate statistical tests. Results The demographic parameters, basal total leukocyte count (TLC), and NLR were comparable between the groups. TLC and NLR were significantly higher in Group G as compared to that in Group S post-operatively. The post-operative rise in TLC and NLR from the basal values was significantly higher in Group G as compared to that in Group S. Conclusions General anesthesia was associated with a greater increase in TLC and NLR when compared with spinal anesthesia.
topic general anesthesia
lymphocytes
neutrophils
neutrophil lymphocyte ratio
spinal anesthesia
url http://ekja.org/upload/pdf/kja-d-19-00022.pdf
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