The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk
Background. Lipid metabolism processes have been implicated in prostate carcinogenesis. Since several pesticides are lipophilic or are metabolized via lipid-related mechanisms, they may interact with variants of genes in the lipid metabolism pathway. Methods. In a nested case-control study of 77...
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2012-01-01
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Series: | Journal of Cancer Epidemiology |
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doaj-d68b3150febe4ba681fb13b1ef1529e52020-11-25T00:39:00ZengHindawi LimitedJournal of Cancer Epidemiology1687-85581687-85662012-01-01201210.1155/2012/358076358076The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer RiskGabriella Andreotti0Stella Koutros1Sonja I. Berndt2Kathryn Hughes Barry3Lifang Hou4Jane A. Hoppin5Dale P. Sandler6Jay H. Lubin7Laurie A. Burdette8Jeffrey Yuenger9Meredith Yeager10Laura E. Beane Freeman11Michael C. R. Alavanja12Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USADepartment of Preventive Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60208, USAEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USAEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USACore Genotyping Facility, NCI-Frederick, SAIC-Frederick Inc., Frederick, MD 21702, USACore Genotyping Facility, NCI-Frederick, SAIC-Frederick Inc., Frederick, MD 21702, USACore Genotyping Facility, NCI-Frederick, SAIC-Frederick Inc., Frederick, MD 21702, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7240, USABackground. Lipid metabolism processes have been implicated in prostate carcinogenesis. Since several pesticides are lipophilic or are metabolized via lipid-related mechanisms, they may interact with variants of genes in the lipid metabolism pathway. Methods. In a nested case-control study of 776 cases and 1444 controls from the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators, we examined the interactions between 39 pesticides (none, low, and high exposure) and 220 single nucleotide polymorphisms (SNPs) in 59 genes. The false discovery rate (FDR) was used to account for multiple comparisons. Results. We found 17 interactions that displayed a significant monotonic increase in prostate cancer risk with pesticide exposure in one genotype and no significant association in the other genotype. The most noteworthy association was for ALOXE3 rs3027208 and terbufos, such that men carrying the T allele who were low users had an OR of 1.86 (95% CI = 1.16–2.99) and high users an OR of 2.00 (95% CI = 1.28–3.15) compared to those with no use of terbufos, while men carrying the CC genotype did not exhibit a significant association. Conclusion. Genetic variation in lipid metabolism genes may modify pesticide associations with prostate cancer; however our results require replication.http://dx.doi.org/10.1155/2012/358076 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gabriella Andreotti Stella Koutros Sonja I. Berndt Kathryn Hughes Barry Lifang Hou Jane A. Hoppin Dale P. Sandler Jay H. Lubin Laurie A. Burdette Jeffrey Yuenger Meredith Yeager Laura E. Beane Freeman Michael C. R. Alavanja |
spellingShingle |
Gabriella Andreotti Stella Koutros Sonja I. Berndt Kathryn Hughes Barry Lifang Hou Jane A. Hoppin Dale P. Sandler Jay H. Lubin Laurie A. Burdette Jeffrey Yuenger Meredith Yeager Laura E. Beane Freeman Michael C. R. Alavanja The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk Journal of Cancer Epidemiology |
author_facet |
Gabriella Andreotti Stella Koutros Sonja I. Berndt Kathryn Hughes Barry Lifang Hou Jane A. Hoppin Dale P. Sandler Jay H. Lubin Laurie A. Burdette Jeffrey Yuenger Meredith Yeager Laura E. Beane Freeman Michael C. R. Alavanja |
author_sort |
Gabriella Andreotti |
title |
The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk |
title_short |
The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk |
title_full |
The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk |
title_fullStr |
The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk |
title_full_unstemmed |
The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk |
title_sort |
interaction between pesticide use and genetic variants involved in lipid metabolism on prostate cancer risk |
publisher |
Hindawi Limited |
series |
Journal of Cancer Epidemiology |
issn |
1687-8558 1687-8566 |
publishDate |
2012-01-01 |
description |
Background. Lipid metabolism processes have been implicated in prostate carcinogenesis. Since several pesticides are lipophilic or are metabolized via lipid-related mechanisms, they may interact with variants of genes in the lipid metabolism pathway. Methods. In a nested case-control study of 776 cases and 1444 controls from the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators, we examined the interactions between 39 pesticides (none, low, and high exposure) and 220 single nucleotide polymorphisms (SNPs) in 59 genes. The false discovery rate (FDR) was used to account for multiple comparisons. Results. We found 17 interactions that displayed a significant monotonic increase in prostate cancer risk with pesticide exposure in one genotype and no significant association in the other genotype. The most noteworthy association was for ALOXE3 rs3027208 and terbufos, such that men carrying the T allele who were low users had an OR of 1.86 (95% CI = 1.16–2.99) and high users an OR of 2.00 (95% CI = 1.28–3.15) compared to those with no use of terbufos, while men carrying the CC genotype did not exhibit a significant association. Conclusion. Genetic variation in lipid metabolism genes may modify pesticide associations with prostate cancer; however our results require replication. |
url |
http://dx.doi.org/10.1155/2012/358076 |
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