A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors

A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors

Notch1 plays a key role in epithelial-mesenchymal transition (EMT) and in the maintenance of cancer stem cells. In the present study we tested whether high levels of activated Notch1 in oncogene-driven NSCLC can induce a reversible shift of driver dependence from EGFR to Notch1, and thus causing res...

Full description

Bibliographic Details
Main Authors: Francesca Iommelli, Viviana De Rosa, Cristina Terlizzi, Rosa Fonti, Rosa Camerlingo, Maria Patrizia Stoppelli, C. Allison Stewart, Lauren Averett Byers, David Piwnica-Worms, Silvana Del Vecchio
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
Notch1
EGFR
EMT
tumor spheres
NSCLC
Online Access:https://www.mdpi.com/2072-6694/13/9/2022

Similar Items

Similar Items