Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission
The pathophysiological neural mechanism underlying the depressogenic and anxiogenic effects of chronic adolescent cannabinoid use may be linked to perturbations in monoaminergic neurotransmission. We tested this hypothesis by administering the CB1 receptor agonist WIN55,212-2, once daily for 20 days...
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doaj-d69cc89c277f459bae7e1fb55e254f1d2021-03-20T04:58:43ZengElsevierNeurobiology of Disease1095-953X2010-03-01373641655Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmissionFrancis Rodriguez Bambico0Nhu-Tram Nguyen1Noam Katz2Gabriella Gobbi3Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1Corresponding author. Fax: +1 514 3984866.; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1The pathophysiological neural mechanism underlying the depressogenic and anxiogenic effects of chronic adolescent cannabinoid use may be linked to perturbations in monoaminergic neurotransmission. We tested this hypothesis by administering the CB1 receptor agonist WIN55,212-2, once daily for 20 days to adolescent and adult rats, subsequently subjecting them to tests for emotional reactivity paralleled by the in vivo extracellular recordings of serotonergic and noradrenergic neurons. Chronic adolescent exposure but not adult exposure to low (0.2 mg/kg) and high (1.0 mg/kg) doses led to depression-like behaviour in the forced swim and sucrose preference test, while the high dose also induced anxiety-like consequences in the novelty-suppressed feeding test. Electrophysiological recordings revealed both doses to have attenuated serotonergic activity, while the high dose also led to a hyperactivity of noradrenergic neurons only after adolescent exposure. These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be instigated by serotonergic hypoactivity and noradrenergic hyperactivity.http://www.sciencedirect.com/science/article/pii/S0969996109003428CannabinoidsAdolescenceSerotoninNorepinephrineAnxietyDepression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francis Rodriguez Bambico Nhu-Tram Nguyen Noam Katz Gabriella Gobbi |
spellingShingle |
Francis Rodriguez Bambico Nhu-Tram Nguyen Noam Katz Gabriella Gobbi Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission Neurobiology of Disease Cannabinoids Adolescence Serotonin Norepinephrine Anxiety Depression |
author_facet |
Francis Rodriguez Bambico Nhu-Tram Nguyen Noam Katz Gabriella Gobbi |
author_sort |
Francis Rodriguez Bambico |
title |
Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission |
title_short |
Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission |
title_full |
Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission |
title_fullStr |
Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission |
title_full_unstemmed |
Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission |
title_sort |
chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2010-03-01 |
description |
The pathophysiological neural mechanism underlying the depressogenic and anxiogenic effects of chronic adolescent cannabinoid use may be linked to perturbations in monoaminergic neurotransmission. We tested this hypothesis by administering the CB1 receptor agonist WIN55,212-2, once daily for 20 days to adolescent and adult rats, subsequently subjecting them to tests for emotional reactivity paralleled by the in vivo extracellular recordings of serotonergic and noradrenergic neurons. Chronic adolescent exposure but not adult exposure to low (0.2 mg/kg) and high (1.0 mg/kg) doses led to depression-like behaviour in the forced swim and sucrose preference test, while the high dose also induced anxiety-like consequences in the novelty-suppressed feeding test. Electrophysiological recordings revealed both doses to have attenuated serotonergic activity, while the high dose also led to a hyperactivity of noradrenergic neurons only after adolescent exposure. These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be instigated by serotonergic hypoactivity and noradrenergic hyperactivity. |
topic |
Cannabinoids Adolescence Serotonin Norepinephrine Anxiety Depression |
url |
http://www.sciencedirect.com/science/article/pii/S0969996109003428 |
work_keys_str_mv |
AT francisrodriguezbambico chronicexposuretocannabinoidsduringadolescencebutnotduringadulthoodimpairsemotionalbehaviourandmonoaminergicneurotransmission AT nhutramnguyen chronicexposuretocannabinoidsduringadolescencebutnotduringadulthoodimpairsemotionalbehaviourandmonoaminergicneurotransmission AT noamkatz chronicexposuretocannabinoidsduringadolescencebutnotduringadulthoodimpairsemotionalbehaviourandmonoaminergicneurotransmission AT gabriellagobbi chronicexposuretocannabinoidsduringadolescencebutnotduringadulthoodimpairsemotionalbehaviourandmonoaminergicneurotransmission |
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