Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-i...
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Wolters Kluwer Medknow Publications
2012-01-01
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doaj-d6b36dc58202472498b7ac34421743b02020-11-24T23:32:59ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792012-01-0145101110.4103/0975-7406.94119Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritisVijay PawarVirpal GohilRiyaj TamboliRajani GiridharMange Ram YadavNSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-imaging studies are carried out. Cartilage targeting strategy for conventional NSAIDs has been explored for reducing their local and systemic side effect of the NSAIDs site specific delivery of quarternary ester derivatives could have to be an effective strategy for long term therapy of inflammatory conditions like arthritis.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=10;epage=11;aulast=PawarCOXNSAIDsarthritis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vijay Pawar Virpal Gohil Riyaj Tamboli Rajani Giridhar Mange Ram Yadav |
spellingShingle |
Vijay Pawar Virpal Gohil Riyaj Tamboli Rajani Giridhar Mange Ram Yadav Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis Journal of Pharmacy and Bioallied Sciences COX NSAIDs arthritis |
author_facet |
Vijay Pawar Virpal Gohil Riyaj Tamboli Rajani Giridhar Mange Ram Yadav |
author_sort |
Vijay Pawar |
title |
Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis |
title_short |
Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis |
title_full |
Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis |
title_fullStr |
Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis |
title_full_unstemmed |
Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis |
title_sort |
cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Pharmacy and Bioallied Sciences |
issn |
0975-7406 0976-4879 |
publishDate |
2012-01-01 |
description |
NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-imaging studies are carried out. Cartilage targeting strategy for conventional NSAIDs has been explored for reducing their local and systemic side effect of the NSAIDs site specific delivery of quarternary ester derivatives could have to be an effective strategy for long term therapy of inflammatory conditions like arthritis. |
topic |
COX NSAIDs arthritis |
url |
http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=10;epage=11;aulast=Pawar |
work_keys_str_mv |
AT vijaypawar cartilagetargetedchemicaldeliveryofnaproxenandibuprofenforthetreatmentofarthritis AT virpalgohil cartilagetargetedchemicaldeliveryofnaproxenandibuprofenforthetreatmentofarthritis AT riyajtamboli cartilagetargetedchemicaldeliveryofnaproxenandibuprofenforthetreatmentofarthritis AT rajanigiridhar cartilagetargetedchemicaldeliveryofnaproxenandibuprofenforthetreatmentofarthritis AT mangeramyadav cartilagetargetedchemicaldeliveryofnaproxenandibuprofenforthetreatmentofarthritis |
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