Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2

Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2

Osteolytic bone lesions are one of the central features of multiple myeloma (MM) and lead to bone pain, fractures, decreased quality of life, and decreased survival. Dysfunction of the osteoclast (OC)/osteoblast (OB) axis plays a key role in the development of myeloma-associated osteolytic lesions....

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Bibliographic Details
Main Authors: Chia-Hung Yen, Chin-Mu Hsu, Samuel Yien Hsiao, Hui-Hua Hsiao
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
nuclear factor erythroid 2-related factor 2 (NRF2)
osteoclast
osteoclastogenesis
osteoblast
multiple myeloma
the receptor activator of NF-kappa B (RANK)
Online Access:https://www.mdpi.com/1422-0067/21/18/6723

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