Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics

Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics

To define the growing significance of cellular targets and/or effectors of cancer drugs, we examined the fitness dependency of cellular targets and effectors of cancer drug targets across human cancer cells from 19 cancer types. We observed that the deletion of 35 out of 47 cellular effectors and/or...

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Bibliographic Details
Main Authors:	Bijesh George, P. Mukundan Pillai, Aswathy Mary Paul, Revikumar Amjesh, Kim Leitzel, Suhail M. Ali, Oleta Sandiford, Allan Lipton, Pranela Rameshwar, Gabriel N. Hortobagyi, Madhavan Radhakrishna Pillai, Rakesh Kumar
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Cells
Subjects:	cancer fitness genes breast cancer hard-to-treat cancers Mevalonate and Purine biosynthesis oncology drugs repurposing
Online Access:	https://www.mdpi.com/2073-4409/10/2/433

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