Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors
Background/Aims: Cigarette smoking is a risk factor for renal damage, but little is known about subclinical effects of smoking on renal hemodynamics and parameters of renal function in humans. We examined the associations of smoking with systemic and renal hemodynamics and renal function parameters...
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2013-12-01
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doaj-d6c6a3f13ad640839074b6b395e02f652020-11-25T02:25:15ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432013-12-0137661162110.1159/000355741355741Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney DonorsHana GuberinaMarcus BaumannHeike BruckThorsten FeldkampJens NürnbergerAndreas KribbenThomas PhilippOliver WitzkeGeorgios SotiropoulosAnna MitchellBackground/Aims: Cigarette smoking is a risk factor for renal damage, but little is known about subclinical effects of smoking on renal hemodynamics and parameters of renal function in humans. We examined the associations of smoking with systemic and renal hemodynamics and renal function parameters in healthy individuals. Methods: Data from 196 potential living kidney donors were analysed retrospectively. Mean arterial blood pressure (MAP), effective renal plasma flow (ERPF) and creatinine clearance had been measured. We additionally calculated parameters of renal hemodynamics. Data were analyzed for the effects of smoking and sex dependent on age and MAP. Results: Systemic and renal hemodynamic parameters did not differ between smokers and non-smokers. In non-smokers of both sexes MAP was negatively correlated with ERPF, and higher MAP was associated with increased renal vascular resistance and with afferent arteriolar resistance, with glomerular pressure (PG) remaining constant. However, in male, but not in female smokers, ERPF and PG increased with MAP. A correlation of age with a steeper decline in ERPF in male smokers was lost in multiple regression analysis. Conclusions: As compared to women, smoking men may exhibit an increased glomerular hydrostatic pressure, which is a known promoter of kidney damage.http://www.karger.com/Article/FullText/355741SmokingRenal hemodynamicsEffective renal plasma flowGlomerular hydrostatic pressure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hana Guberina Marcus Baumann Heike Bruck Thorsten Feldkamp Jens Nürnberger Andreas Kribben Thomas Philipp Oliver Witzke Georgios Sotiropoulos Anna Mitchell |
spellingShingle |
Hana Guberina Marcus Baumann Heike Bruck Thorsten Feldkamp Jens Nürnberger Andreas Kribben Thomas Philipp Oliver Witzke Georgios Sotiropoulos Anna Mitchell Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors Kidney & Blood Pressure Research Smoking Renal hemodynamics Effective renal plasma flow Glomerular hydrostatic pressure |
author_facet |
Hana Guberina Marcus Baumann Heike Bruck Thorsten Feldkamp Jens Nürnberger Andreas Kribben Thomas Philipp Oliver Witzke Georgios Sotiropoulos Anna Mitchell |
author_sort |
Hana Guberina |
title |
Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors |
title_short |
Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors |
title_full |
Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors |
title_fullStr |
Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors |
title_full_unstemmed |
Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors |
title_sort |
associations of smoking with alterations in renal hemodynamics may depend on sex- investigations in potential kidney donors |
publisher |
Karger Publishers |
series |
Kidney & Blood Pressure Research |
issn |
1420-4096 1423-0143 |
publishDate |
2013-12-01 |
description |
Background/Aims: Cigarette smoking is a risk factor for renal damage, but little is known about subclinical effects of smoking on renal hemodynamics and parameters of renal function in humans. We examined the associations of smoking with systemic and renal hemodynamics and renal function parameters in healthy individuals. Methods: Data from 196 potential living kidney donors were analysed retrospectively. Mean arterial blood pressure (MAP), effective renal plasma flow (ERPF) and creatinine clearance had been measured. We additionally calculated parameters of renal hemodynamics. Data were analyzed for the effects of smoking and sex dependent on age and MAP. Results: Systemic and renal hemodynamic parameters did not differ between smokers and non-smokers. In non-smokers of both sexes MAP was negatively correlated with ERPF, and higher MAP was associated with increased renal vascular resistance and with afferent arteriolar resistance, with glomerular pressure (PG) remaining constant. However, in male, but not in female smokers, ERPF and PG increased with MAP. A correlation of age with a steeper decline in ERPF in male smokers was lost in multiple regression analysis. Conclusions: As compared to women, smoking men may exhibit an increased glomerular hydrostatic pressure, which is a known promoter of kidney damage. |
topic |
Smoking Renal hemodynamics Effective renal plasma flow Glomerular hydrostatic pressure |
url |
http://www.karger.com/Article/FullText/355741 |
work_keys_str_mv |
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