Biochemical Markers in Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the most frequent neurodegenerative diseases affecting more than 35 million people in the world, and its incidence is estimated to triple by 2050. Alzheimer’s disease is an age-related disease characterized by the progressive loss of memory and...
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doaj-d6c74e6b04b54158bec8c5039201e39b2020-11-25T01:41:51ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01216198910.3390/ijms21061989ijms21061989Biochemical Markers in Alzheimer’s DiseaseAlessandro Rabbito0Maciej Dulewicz1Agnieszka Kulczyńska-Przybik2Barbara Mroczko3Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Białystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Białystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Białystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Białystok, PolandAlzheimer’s disease (AD) is one of the most frequent neurodegenerative diseases affecting more than 35 million people in the world, and its incidence is estimated to triple by 2050. Alzheimer’s disease is an age-related disease characterized by the progressive loss of memory and cognitive function, caused by the unstoppable neurodegeneration and brain atrophy. Current AD treatments only relieve the symptoms. The first molecular signs of the disease identified decades ago and were related to the tau neurofibrillary tangles and the β amyloid plaques. Despite the considerable progress in the diagnostic field, there is no certain knowledge of the specific biomarkers reflecting molecular mechanisms that trigger the symptoms of the disease. Therefore, there is an enormous need to find biomarkers useful for early diagnosis, before the first symptoms appear, and develop new therapeutic targets, which would guarantee improving patients’ quality of life. Researchers from all around the world are looking for biomarkers that can be identified in different biological fluids such as plasma, serum, and cerebrospinal fluid, specific for Alzheimer’s disease. In this review, we would like to resume some of the most interesting discovery in pathological mechanisms underlying Alzheimer’s disease and promising biomarkers.https://www.mdpi.com/1422-0067/21/6/1989alzheimer’s diseasebiomarkersdiagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessandro Rabbito Maciej Dulewicz Agnieszka Kulczyńska-Przybik Barbara Mroczko |
spellingShingle |
Alessandro Rabbito Maciej Dulewicz Agnieszka Kulczyńska-Przybik Barbara Mroczko Biochemical Markers in Alzheimer’s Disease International Journal of Molecular Sciences alzheimer’s disease biomarkers diagnosis |
author_facet |
Alessandro Rabbito Maciej Dulewicz Agnieszka Kulczyńska-Przybik Barbara Mroczko |
author_sort |
Alessandro Rabbito |
title |
Biochemical Markers in Alzheimer’s Disease |
title_short |
Biochemical Markers in Alzheimer’s Disease |
title_full |
Biochemical Markers in Alzheimer’s Disease |
title_fullStr |
Biochemical Markers in Alzheimer’s Disease |
title_full_unstemmed |
Biochemical Markers in Alzheimer’s Disease |
title_sort |
biochemical markers in alzheimer’s disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2020-03-01 |
description |
Alzheimer’s disease (AD) is one of the most frequent neurodegenerative diseases affecting more than 35 million people in the world, and its incidence is estimated to triple by 2050. Alzheimer’s disease is an age-related disease characterized by the progressive loss of memory and cognitive function, caused by the unstoppable neurodegeneration and brain atrophy. Current AD treatments only relieve the symptoms. The first molecular signs of the disease identified decades ago and were related to the tau neurofibrillary tangles and the β amyloid plaques. Despite the considerable progress in the diagnostic field, there is no certain knowledge of the specific biomarkers reflecting molecular mechanisms that trigger the symptoms of the disease. Therefore, there is an enormous need to find biomarkers useful for early diagnosis, before the first symptoms appear, and develop new therapeutic targets, which would guarantee improving patients’ quality of life. Researchers from all around the world are looking for biomarkers that can be identified in different biological fluids such as plasma, serum, and cerebrospinal fluid, specific for Alzheimer’s disease. In this review, we would like to resume some of the most interesting discovery in pathological mechanisms underlying Alzheimer’s disease and promising biomarkers. |
topic |
alzheimer’s disease biomarkers diagnosis |
url |
https://www.mdpi.com/1422-0067/21/6/1989 |
work_keys_str_mv |
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