Glial Tau Pathology in Tauopathies: Functional Consequences

Glial Tau Pathology in Tauopathies: Functional Consequences

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Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating b...

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Main Authors: Martha A. Kahlson, Kenneth J. Colodner
Format: Article
Language:English
Published: SAGE Publishing 2015-01-01
Series:Journal of Experimental Neuroscience
Online Access:https://doi.org/10.4137/JEN.S25515
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spelling doaj-d6d4fe22dbaf4d51b0e04515ac1de81f2020-11-25T02:34:08ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952015-01-019s210.4137/JEN.S25515Glial Tau Pathology in Tauopathies: Functional ConsequencesMartha A. Kahlson0Kenneth J. Colodner1Department of Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA, USA.Department of Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA, USA.Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences of tau pathology in neurons, the relative contribution of glial tau pathology to these diseases is less clear. Recent studies using a number of model systems implicate glial tau pathology in contributing to tauopathy pathogenesis. This review aims to highlight the functional consequences of tau overexpression in glial cells and explore the potential contribution of glial tau pathology in the pathogenesis of neurodegenerative tauopathies.https://doi.org/10.4137/JEN.S25515
collection DOAJ
language English
format Article
sources DOAJ
author Martha A. Kahlson
Kenneth J. Colodner
spellingShingle Martha A. Kahlson
Kenneth J. Colodner
Glial Tau Pathology in Tauopathies: Functional Consequences
Journal of Experimental Neuroscience
author_facet Martha A. Kahlson
Kenneth J. Colodner
author_sort Martha A. Kahlson
title Glial Tau Pathology in Tauopathies: Functional Consequences
title_short Glial Tau Pathology in Tauopathies: Functional Consequences
title_full Glial Tau Pathology in Tauopathies: Functional Consequences
title_fullStr Glial Tau Pathology in Tauopathies: Functional Consequences
title_full_unstemmed Glial Tau Pathology in Tauopathies: Functional Consequences
title_sort glial tau pathology in tauopathies: functional consequences
publisher SAGE Publishing
series Journal of Experimental Neuroscience
issn 1179-0695
publishDate 2015-01-01
description Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences of tau pathology in neurons, the relative contribution of glial tau pathology to these diseases is less clear. Recent studies using a number of model systems implicate glial tau pathology in contributing to tauopathy pathogenesis. This review aims to highlight the functional consequences of tau overexpression in glial cells and explore the potential contribution of glial tau pathology in the pathogenesis of neurodegenerative tauopathies.
url https://doi.org/10.4137/JEN.S25515
work_keys_str_mv AT marthaakahlson glialtaupathologyintauopathiesfunctionalconsequences
AT kennethjcolodner glialtaupathologyintauopathiesfunctionalconsequences
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