Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging

Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging

Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal imaging during pre-clinical studies has been increasingly used to localise the ga...

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Bibliographic Details
Main Authors: Noemí Gómez-Lado, Iria Seoane-Viaño, Silvia Matiz, Christine M. Madla, Vipul Yadav, Pablo Aguiar, Abdul W. Basit, Alvaro Goyanes
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
medical imaging
computed tomography
anesthesia
capsule size
gastric emptying
rodents
gastrointestinal tract
oral drug delivery
drug absorption
Online Access:https://www.mdpi.com/1999-4923/12/1/81

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https://www.mdpi.com/1999-4923/12/1/81

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