O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.

O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.

O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) is the only enzyme catalyzing O-GlcNAcylation. Although it has been shown that OGT plays an essential role in maintaining postnatal heart function, its role in heart development remains unknown. Here we showed that loss of OGT in early fetal ca...

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Bibliographic Details
Main Authors: Yongxin Mu, Houzhi Yu, Tongbin Wu, Jianlin Zhang, Sylvia M Evans, Ju Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008730

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