Valproic acid treatment inhibits hypoxia-inducible factor 1α accumulation and protects against burn-induced gut barrier dysfunction in a rodent model.

Valproic acid treatment inhibits hypoxia-inducible factor 1α accumulation and protects against burn-induced gut barrier dysfunction in a rodent model.

OBJECTIVE:Burn-induced gut dysfunction plays an important role in the development of sepsis and multiple organ dysfunction. Emerging evidence suggests that hypoxia-inducible factor-1α (HIF-1α) is critical in paracellular barrier functions via regulating vascular endothelial growth factor (VEGF) and...

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Bibliographic Details
Main Authors: Hong-Min Luo, Ming-Hua Du, Zhi-Long Lin, Lin Zhang, Li Ma, Huan Wang, Wen Yu, Yi Lv, Jiang-Yang Lu, Yu-Li Pi, Sen Hu, Zhi-Yong Sheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3798300?pdf=render

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