Mast Cells and Nerve Signal Conduction in Acupuncture
Nerve and mast cells are densely distributed around acupoints in connective tissue. To explore the internal relations between them in acupuncture effect, we examined dorsal root potential (DRP) response to acupuncture at Zusanli (ST36) under sodium cromoglicate (DSCG, a mast cell stabilizer) interve...
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2018-01-01
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doaj-d6eb92f353114edc8dc7b0a1853b630a2020-11-24T22:10:29ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882018-01-01201810.1155/2018/35242793524279Mast Cells and Nerve Signal Conduction in AcupunctureNa Yin0Hongwei Yang1Wei Yao2Ying Xia3Guanghong Ding4Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Aeronautics and Astronautics, Fudan University, Shanghai 200433, ChinaShanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Aeronautics and Astronautics, Fudan University, Shanghai 200433, ChinaShanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Aeronautics and Astronautics, Fudan University, Shanghai 200433, ChinaShanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Aeronautics and Astronautics, Fudan University, Shanghai 200433, ChinaShanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Aeronautics and Astronautics, Fudan University, Shanghai 200433, ChinaNerve and mast cells are densely distributed around acupoints in connective tissue. To explore the internal relations between them in acupuncture effect, we examined dorsal root potential (DRP) response to acupuncture at Zusanli (ST36) under sodium cromoglicate (DSCG, a mast cell stabilizer) intervention in anesthetized Sprague-Dawley (SD) rats. We used single unit nerve recording techniques to collect nerve signals from DRP afferent nerves for a 45-minute period that includes 4 stages, that is, base, drug absorption, acupuncture, and recovery stages. We analyzed the recorded signals from time-domain and frequency-domain perspectives. The results showed that once acupuncture needle was inserted, twisting needle excited more nerves discharges than those at base discharges in ACU (from 35.1 ± 7.2 to 47 ± 9.2 Hz, P=0.004), and there existed the same trend in Saline + ACU group (from 23.8 ± 2.6 to 29.8 ± 4.2 Hz, P=0.059). There was no change of nerve discharges under twisting needle with injection of DSCG (from 34.8 ± 5.3 to 34.7 ± 4.4 Hz, P=0.480). We conclude that acupuncture manipulation promotes neural signal production and DSCG could partly inhibit nerve discharges.http://dx.doi.org/10.1155/2018/3524279 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Na Yin Hongwei Yang Wei Yao Ying Xia Guanghong Ding |
spellingShingle |
Na Yin Hongwei Yang Wei Yao Ying Xia Guanghong Ding Mast Cells and Nerve Signal Conduction in Acupuncture Evidence-Based Complementary and Alternative Medicine |
author_facet |
Na Yin Hongwei Yang Wei Yao Ying Xia Guanghong Ding |
author_sort |
Na Yin |
title |
Mast Cells and Nerve Signal Conduction in Acupuncture |
title_short |
Mast Cells and Nerve Signal Conduction in Acupuncture |
title_full |
Mast Cells and Nerve Signal Conduction in Acupuncture |
title_fullStr |
Mast Cells and Nerve Signal Conduction in Acupuncture |
title_full_unstemmed |
Mast Cells and Nerve Signal Conduction in Acupuncture |
title_sort |
mast cells and nerve signal conduction in acupuncture |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2018-01-01 |
description |
Nerve and mast cells are densely distributed around acupoints in connective tissue. To explore the internal relations between them in acupuncture effect, we examined dorsal root potential (DRP) response to acupuncture at Zusanli (ST36) under sodium cromoglicate (DSCG, a mast cell stabilizer) intervention in anesthetized Sprague-Dawley (SD) rats. We used single unit nerve recording techniques to collect nerve signals from DRP afferent nerves for a 45-minute period that includes 4 stages, that is, base, drug absorption, acupuncture, and recovery stages. We analyzed the recorded signals from time-domain and frequency-domain perspectives. The results showed that once acupuncture needle was inserted, twisting needle excited more nerves discharges than those at base discharges in ACU (from 35.1 ± 7.2 to 47 ± 9.2 Hz, P=0.004), and there existed the same trend in Saline + ACU group (from 23.8 ± 2.6 to 29.8 ± 4.2 Hz, P=0.059). There was no change of nerve discharges under twisting needle with injection of DSCG (from 34.8 ± 5.3 to 34.7 ± 4.4 Hz, P=0.480). We conclude that acupuncture manipulation promotes neural signal production and DSCG could partly inhibit nerve discharges. |
url |
http://dx.doi.org/10.1155/2018/3524279 |
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