Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer

Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer

Carcinogenesis is linked with massive changes in regulation of gene networks. We used high throughput mutation and gene expression data to interrogate involvement of 278 signaling, 72 metabolic, 48 DNA repair and 47 cytoskeleton molecular pathways in cancer. Totally, we analyzed 4910 primary tumor s...

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Bibliographic Details
Main Authors: Marianna A. Zolotovskaia, Victor S. Tkachev, Alexander P. Seryakov, Denis V. Kuzmin, Dmitry E. Kamashev, Maxim I. Sorokin, Sergey A. Roumiantsev, Anton A. Buzdin
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
cancer
dna mutation
intracellular molecular pathways
carcinogenesis
transcriptome
molecular pathway activation
Online Access:https://www.mdpi.com/2072-6694/12/2/271

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