The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development

• Main Authors: Marek Paździor, Małgorzata Kiełczykowska, Jacek Kurzepa, Dorota Luchowska-Kocot, Joanna Kocot, Irena Musik
• Format: Article
• Language: English
• Published: MDPI AG 2019-05-01
• Series: Medicina
• Subjects: knee OA; total antioxidant status; superoxide dismutase; glutathione peroxidase; catalase; gender
• Online Access: https://www.mdpi.com/1010-660X/55/5/150

<i>Background and </i><i>Objective</i><i>:</i> Osteoarthritis (OA) is a disorder of the musculoskeletal system resulting in worsening of life condition. The research revealed the involvement of oxidative stress into both OA pathogenesis and the effects of therapeutic agents applied in OA cases. The activities of the most important antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and total antioxidant status (TAS), in blood of the knee OA patients were studied, with the aim of clarifying which enzymatic antioxidants are involved into osteoarthritis (OA)-related oxidative stress and whether any compensatory effects occur. The results were additionally analyzed with regard to gender. <i>Method</i>s: Whole blood SOD (U/mL), plasma GPx (U/L) and CAT (U/mL) activities as well as plasma TAS (mmol/L)) in knee OA patients were investigated. Sixty-seven patients (49 females and 18 males) with primary knee OA were enrolled. The control comprised 21 subjects (10 females and 11 males) free of osteoarthritis or inflammation. <i>Results</i>: TAS was decreased in OA subjects (4.39 0.53 vs. 4.70 0.60), with this effect being more significant in OA females (4.31 0.51 vs. 5.02 0.54). GPx was depressed in all OA patients (518 176 vs. 675 149). In both genders, GPx was decreased, significantly in males (482 185 vs. 715 105). SOD was decreased in all OA patients (109 32 vs. 127 42). CAT showed no difference in all OA subjects vs. control, while in OA females it was depleted (20.2 (11.6&#8211;31.6) vs. 38.5 (27.9&#8211;46.6)) and in OA men it increased (26.9 (23.3&#8211;46.5) vs. 14.0 (7.0&#8211;18.6)). <i>Conclusions</i>: The obtained results suggest that in men some compensatory mechanisms towards OA-related oxidative stress occurred. Based on the obtained data, the introduction of antioxidant supplements into OA therapy could be suggested with further research concerning the choice of agents.