Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention

Abstract Background Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the design and sample size of the adequa...

Full description

Bibliographic Details
Main Authors: Ravinder Claire, Christian Gluud, Ivan Berlin, Tim Coleman, Jo Leonardi-Bee
Format: Article
Published: BMC 2020-11-01
Series:BMC Medical Research Methodology
Online Access: