Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis
Background/Aims To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this...
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doaj-d70ec679ba084df3a067b2e39c1092242021-08-10T01:10:39ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-07-0134491091610.3904/kjim.2017.113169986Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritisSoo-Kyoung Cho0Dam Kim1Soyoung Won2Jiyoung Lee3Chan-Bum Choi4Jung-Yoon Choe5Seung-Jae Hong6Jae-Bum Jun7Tae-Hwan Kim8Eunmi Koh9Hye-Soon Lee10Jisoo Lee11Dae-Hyun Yoo12Bo Young Yoon13Sang-Cheol Bae14Yoon-Kyoung Sung15the Korean Observational Study Network for Arthritis (KORONA) Investigators Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Korea Department of Rheumatology, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Catholic University of Daegu School of Medicine, Daegu, Korea Department of Rheumatology, Kyung Hee University Medical Center, Seoul, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Rheumatology, Hanyang University Guri Hospital, Guri, Korea Department of Rheumatology, Ewha Womans University Mokdong Hospital, Seoul, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, KoreaBackground/Aims To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis > 1 year). Using the multivariable regression model, we identified factors associated with early diagnosis. Results Among 714 early RA patients, 401 patients (56.2%) and 313 patients (43.8%) were included in the early diagnosis and late diagnosis groups, respectively. The mean disease duration was 0.47 years in the early diagnosis group and 0.45 years in the late diagnosis group. In multivariable model analysis, greater age at onset (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.02 to 1.05), high school education or higher (OR, 1.68; 95% CI, 1.14 to 2.47), higher income (OR, 1.48; 95% CI, 1.05 to 2.08), and initial small joint involvement (OR, 1.42; 95% CI, 1.02 to 1.98) were factors associated with early diagnosis. At diagnosis, disease activity scores using 28 joints on diagnosis (3.81 ± 1.44 vs. 3.82 ± 1.42, p = 0.92) and functional disability (0.65 ± 0.61 vs. 0.57 ± 0.62, p = 0.07) did not different between the two groups. However, hand joint erosion on X-ray (37.8% vs. 25.6%, p < 0.01) was more common in the late diagnosis group than the early diagnosis group. Conclusions Older onset age, higher educational level and income, and initial small joint involvement were positive factors for early diagnosis of RA.http://www.kjim.org/upload/pdf/kjim-2017-113.pdfearly diagnosisarthritis, rheumatoid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soo-Kyoung Cho Dam Kim Soyoung Won Jiyoung Lee Chan-Bum Choi Jung-Yoon Choe Seung-Jae Hong Jae-Bum Jun Tae-Hwan Kim Eunmi Koh Hye-Soon Lee Jisoo Lee Dae-Hyun Yoo Bo Young Yoon Sang-Cheol Bae Yoon-Kyoung Sung the Korean Observational Study Network for Arthritis (KORONA) Investigators |
spellingShingle |
Soo-Kyoung Cho Dam Kim Soyoung Won Jiyoung Lee Chan-Bum Choi Jung-Yoon Choe Seung-Jae Hong Jae-Bum Jun Tae-Hwan Kim Eunmi Koh Hye-Soon Lee Jisoo Lee Dae-Hyun Yoo Bo Young Yoon Sang-Cheol Bae Yoon-Kyoung Sung the Korean Observational Study Network for Arthritis (KORONA) Investigators Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis The Korean Journal of Internal Medicine early diagnosis arthritis, rheumatoid |
author_facet |
Soo-Kyoung Cho Dam Kim Soyoung Won Jiyoung Lee Chan-Bum Choi Jung-Yoon Choe Seung-Jae Hong Jae-Bum Jun Tae-Hwan Kim Eunmi Koh Hye-Soon Lee Jisoo Lee Dae-Hyun Yoo Bo Young Yoon Sang-Cheol Bae Yoon-Kyoung Sung the Korean Observational Study Network for Arthritis (KORONA) Investigators |
author_sort |
Soo-Kyoung Cho |
title |
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis |
title_short |
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis |
title_full |
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis |
title_fullStr |
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis |
title_full_unstemmed |
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis |
title_sort |
factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2019-07-01 |
description |
Background/Aims To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis > 1 year). Using the multivariable regression model, we identified factors associated with early diagnosis. Results Among 714 early RA patients, 401 patients (56.2%) and 313 patients (43.8%) were included in the early diagnosis and late diagnosis groups, respectively. The mean disease duration was 0.47 years in the early diagnosis group and 0.45 years in the late diagnosis group. In multivariable model analysis, greater age at onset (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.02 to 1.05), high school education or higher (OR, 1.68; 95% CI, 1.14 to 2.47), higher income (OR, 1.48; 95% CI, 1.05 to 2.08), and initial small joint involvement (OR, 1.42; 95% CI, 1.02 to 1.98) were factors associated with early diagnosis. At diagnosis, disease activity scores using 28 joints on diagnosis (3.81 ± 1.44 vs. 3.82 ± 1.42, p = 0.92) and functional disability (0.65 ± 0.61 vs. 0.57 ± 0.62, p = 0.07) did not different between the two groups. However, hand joint erosion on X-ray (37.8% vs. 25.6%, p < 0.01) was more common in the late diagnosis group than the early diagnosis group. Conclusions Older onset age, higher educational level and income, and initial small joint involvement were positive factors for early diagnosis of RA. |
topic |
early diagnosis arthritis, rheumatoid |
url |
http://www.kjim.org/upload/pdf/kjim-2017-113.pdf |
work_keys_str_mv |
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