Neuroprotective Effects of Stem Cells in Ischemic Stroke

Neuroprotective Effects of Stem Cells in Ischemic Stroke

Ischemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches...

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Main Authors: Weilin Xu, Jingwei Zheng, Liansheng Gao, Tao Li, Jianmin Zhang, Anwen Shao
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2017/4653936
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spelling doaj-d71d645d2b5045ffab4e4b56c9a306132020-11-24T22:54:21ZengHindawi LimitedStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/46539364653936Neuroprotective Effects of Stem Cells in Ischemic StrokeWeilin Xu0Jingwei Zheng1Liansheng Gao2Tao Li3Jianmin Zhang4Anwen Shao5Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaIschemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches in animal models of stroke have demonstrated the promising efficacy in treating ischemic stroke. The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. This review would focus on the types and neuroprotective actions of stem cells and its potential mechanisms for ischemic stroke.http://dx.doi.org/10.1155/2017/4653936
collection DOAJ
language English
format Article
sources DOAJ
author Weilin Xu
Jingwei Zheng
Liansheng Gao
Tao Li
Jianmin Zhang
Anwen Shao
spellingShingle Weilin Xu
Jingwei Zheng
Liansheng Gao
Tao Li
Jianmin Zhang
Anwen Shao
Neuroprotective Effects of Stem Cells in Ischemic Stroke
Stem Cells International
author_facet Weilin Xu
Jingwei Zheng
Liansheng Gao
Tao Li
Jianmin Zhang
Anwen Shao
author_sort Weilin Xu
title Neuroprotective Effects of Stem Cells in Ischemic Stroke
title_short Neuroprotective Effects of Stem Cells in Ischemic Stroke
title_full Neuroprotective Effects of Stem Cells in Ischemic Stroke
title_fullStr Neuroprotective Effects of Stem Cells in Ischemic Stroke
title_full_unstemmed Neuroprotective Effects of Stem Cells in Ischemic Stroke
title_sort neuroprotective effects of stem cells in ischemic stroke
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2017-01-01
description Ischemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches in animal models of stroke have demonstrated the promising efficacy in treating ischemic stroke. The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. This review would focus on the types and neuroprotective actions of stem cells and its potential mechanisms for ischemic stroke.
url http://dx.doi.org/10.1155/2017/4653936
work_keys_str_mv AT weilinxu neuroprotectiveeffectsofstemcellsinischemicstroke
AT jingweizheng neuroprotectiveeffectsofstemcellsinischemicstroke
AT lianshenggao neuroprotectiveeffectsofstemcellsinischemicstroke
AT taoli neuroprotectiveeffectsofstemcellsinischemicstroke
AT jianminzhang neuroprotectiveeffectsofstemcellsinischemicstroke
AT anwenshao neuroprotectiveeffectsofstemcellsinischemicstroke
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