Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging
Mesenchymal stem cells (MSCs) are being widely researched upon for several years with translational application in regenerative medicine. Many studies acknowledged trophic factors from MSCs, attenuating dreadful ailments. The beneficial properties of MSCs are attributed to their secretion of paracri...
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doaj-d71dcf6c1d434ac4ad5108db37f011d82021-09-17T04:36:21ZengElsevierBiotechnology Reports2215-017X2021-09-0131e00658Current understanding of the mesenchymal stem cell-derived exosomes in cancer and agingMakalakshmi Muralikumar0Samatha Manoj Jain1Harsha Ganesan2Asim K Duttaroy3Surajit Pathak4Antara Banerjee5Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, IndiaDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, IndiaDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, IndiaDepartment of Nutrition, IMB, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, IndiaDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, Tamil Nadu, India; Corresponding author.Mesenchymal stem cells (MSCs) are being widely researched upon for several years with translational application in regenerative medicine. Many studies acknowledged trophic factors from MSCs, attenuating dreadful ailments. The beneficial properties of MSCs are attributed to their secretion of paracrine factors as extracellular vesicles/ exosomes in the tissue microenvironment. Exosomes are nano-sized vesicles involved in genetic material transportation and intercellular communication. Exosomes have been recently reported to play a role in cell-free therapy in treating many diseases like cancer and aging and are reported in regulating tumor cell fate. This review highlights the recent advances and current understanding in assessing mesenchymal stem cell-derived exosomes for possible cell-free therapy. The sources and composition of exosomes, drug delivery effectiveness, immunomodulatory property, therapeutic advances in cancer, and aging targeting exosomes as cargo or its effect to moderate the tissue microenvironment are also discussed. We summarize the regenerative mechanisms induced by MSCs derived exosomes.http://www.sciencedirect.com/science/article/pii/S2215017X21000746ExosomesMesenchymal stem cellsCancerTissue regenerationCargoTherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Makalakshmi Muralikumar Samatha Manoj Jain Harsha Ganesan Asim K Duttaroy Surajit Pathak Antara Banerjee |
spellingShingle |
Makalakshmi Muralikumar Samatha Manoj Jain Harsha Ganesan Asim K Duttaroy Surajit Pathak Antara Banerjee Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging Biotechnology Reports Exosomes Mesenchymal stem cells Cancer Tissue regeneration Cargo Therapy |
author_facet |
Makalakshmi Muralikumar Samatha Manoj Jain Harsha Ganesan Asim K Duttaroy Surajit Pathak Antara Banerjee |
author_sort |
Makalakshmi Muralikumar |
title |
Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging |
title_short |
Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging |
title_full |
Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging |
title_fullStr |
Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging |
title_full_unstemmed |
Current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging |
title_sort |
current understanding of the mesenchymal stem cell-derived exosomes in cancer and aging |
publisher |
Elsevier |
series |
Biotechnology Reports |
issn |
2215-017X |
publishDate |
2021-09-01 |
description |
Mesenchymal stem cells (MSCs) are being widely researched upon for several years with translational application in regenerative medicine. Many studies acknowledged trophic factors from MSCs, attenuating dreadful ailments. The beneficial properties of MSCs are attributed to their secretion of paracrine factors as extracellular vesicles/ exosomes in the tissue microenvironment. Exosomes are nano-sized vesicles involved in genetic material transportation and intercellular communication. Exosomes have been recently reported to play a role in cell-free therapy in treating many diseases like cancer and aging and are reported in regulating tumor cell fate. This review highlights the recent advances and current understanding in assessing mesenchymal stem cell-derived exosomes for possible cell-free therapy. The sources and composition of exosomes, drug delivery effectiveness, immunomodulatory property, therapeutic advances in cancer, and aging targeting exosomes as cargo or its effect to moderate the tissue microenvironment are also discussed. We summarize the regenerative mechanisms induced by MSCs derived exosomes. |
topic |
Exosomes Mesenchymal stem cells Cancer Tissue regeneration Cargo Therapy |
url |
http://www.sciencedirect.com/science/article/pii/S2215017X21000746 |
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