Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanisti...

Full description

Bibliographic Details
Main Authors: Daniela Amaral-Silva, Rute Gonçalves, Rita C. Torrão, Rita Torres, Sandra Falcão, Maria João Gonçalves, Maria Paula Araújo, Maria José Martins, Carina Lopes, Agna Neto, José Marona, Tiago Costa, Walter Castelão, Ana Bento Silva, Inês Silva, Maria Helena Lourenço, Margarida Mateus, Nuno Pina Gonçalves, Santiago Manica, Manuela Costa, Fernando M. Pimentel-Santos, Ana Filipa Mourão, Jaime C. Branco, Helena Soares
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02659-0
id doaj-d73f6ecb04594d11b6f47f71dd2151e3
record_format Article
spelling doaj-d73f6ecb04594d11b6f47f71dd2151e32021-10-03T11:15:30ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111610.1038/s42003-021-02659-0Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patientsDaniela Amaral-Silva0Rute Gonçalves1Rita C. Torrão2Rita Torres3Sandra Falcão4Maria João Gonçalves5Maria Paula Araújo6Maria José Martins7Carina Lopes8Agna Neto9José Marona10Tiago Costa11Walter Castelão12Ana Bento Silva13Inês Silva14Maria Helena Lourenço15Margarida Mateus16Nuno Pina Gonçalves17Santiago Manica18Manuela Costa19Fernando M. Pimentel-Santos20Ana Filipa Mourão21Jaime C. Branco22Helena Soares23Human Immunobiology and Pathogenesis GroupHuman Immunobiology and Pathogenesis GroupHuman Immunobiology and Pathogenesis GroupiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisboniNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisbonHospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisbonHospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126Hospital Egas Moniz, Rua da Junqueira n° 126iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisboniNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisbonHospital Egas Moniz, Rua da Junqueira n° 126iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisboniNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of LisbonHospital Egas Moniz, Rua da Junqueira n° 126Human Immunobiology and Pathogenesis GroupIn order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4+ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program.https://doi.org/10.1038/s42003-021-02659-0
collection DOAJ
language English
format Article
sources DOAJ
author Daniela Amaral-Silva
Rute Gonçalves
Rita C. Torrão
Rita Torres
Sandra Falcão
Maria João Gonçalves
Maria Paula Araújo
Maria José Martins
Carina Lopes
Agna Neto
José Marona
Tiago Costa
Walter Castelão
Ana Bento Silva
Inês Silva
Maria Helena Lourenço
Margarida Mateus
Nuno Pina Gonçalves
Santiago Manica
Manuela Costa
Fernando M. Pimentel-Santos
Ana Filipa Mourão
Jaime C. Branco
Helena Soares
spellingShingle Daniela Amaral-Silva
Rute Gonçalves
Rita C. Torrão
Rita Torres
Sandra Falcão
Maria João Gonçalves
Maria Paula Araújo
Maria José Martins
Carina Lopes
Agna Neto
José Marona
Tiago Costa
Walter Castelão
Ana Bento Silva
Inês Silva
Maria Helena Lourenço
Margarida Mateus
Nuno Pina Gonçalves
Santiago Manica
Manuela Costa
Fernando M. Pimentel-Santos
Ana Filipa Mourão
Jaime C. Branco
Helena Soares
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
Communications Biology
author_facet Daniela Amaral-Silva
Rute Gonçalves
Rita C. Torrão
Rita Torres
Sandra Falcão
Maria João Gonçalves
Maria Paula Araújo
Maria José Martins
Carina Lopes
Agna Neto
José Marona
Tiago Costa
Walter Castelão
Ana Bento Silva
Inês Silva
Maria Helena Lourenço
Margarida Mateus
Nuno Pina Gonçalves
Santiago Manica
Manuela Costa
Fernando M. Pimentel-Santos
Ana Filipa Mourão
Jaime C. Branco
Helena Soares
author_sort Daniela Amaral-Silva
title Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
title_short Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
title_full Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
title_fullStr Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
title_full_unstemmed Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
title_sort direct tissue-sensing reprograms tlr4+ tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4+ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program.
url https://doi.org/10.1038/s42003-021-02659-0
work_keys_str_mv AT danielaamaralsilva directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT rutegoncalves directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT ritactorrao directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT ritatorres directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT sandrafalcao directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT mariajoaogoncalves directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT mariapaulaaraujo directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT mariajosemartins directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT carinalopes directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT agnaneto directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT josemarona directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT tiagocosta directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT waltercastelao directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT anabentosilva directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT inessilva directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT mariahelenalourenco directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT margaridamateus directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT nunopinagoncalves directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT santiagomanica directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT manuelacosta directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT fernandompimentelsantos directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT anafilipamourao directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT jaimecbranco directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
AT helenasoares directtissuesensingreprogramstlr4tfhlikecellsinflammatoryprofileinthejointsofrheumatoidarthritispatients
_version_ 1716845609647865856

Similar Items