Structural insights into TSC complex assembly and GAP activity on Rheb

Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydroly...

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Main Authors:	Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20522-4

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spelling	doaj-d745e4d05ea7420aab143072e24bf7712021-01-17T12:13:31ZengNature Publishing GroupNature Communications2041-17232021-01-0112111010.1038/s41467-020-20522-4Structural insights into TSC complex assembly and GAP activity on RhebHuirong Yang0Zishuo Yu1Xizi Chen2Jiabei Li3Ningning Li4Jiaxuan Cheng5Ning Gao6Hai-Xin Yuan7Dan Ye8Kun-Liang Guan9Yanhui Xu10Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan UniversityFudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan UniversityFudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan UniversityFudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan UniversityState Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking UniversityState Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking UniversityState Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking UniversityThe Molecular and Cell Biology Research Lab, The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan UniversityThe Molecular and Cell Biology Research Lab, The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan UniversityDepartment of Pharmacology and Moores Cancer Center, University of California San DiegoFudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan UniversityTuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.https://doi.org/10.1038/s41467-020-20522-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Huirong Yang Zishuo Yu Xizi Chen Jiabei Li Ningning Li Jiaxuan Cheng Ning Gao Hai-Xin Yuan Dan Ye Kun-Liang Guan Yanhui Xu
spellingShingle	Huirong Yang Zishuo Yu Xizi Chen Jiabei Li Ningning Li Jiaxuan Cheng Ning Gao Hai-Xin Yuan Dan Ye Kun-Liang Guan Yanhui Xu Structural insights into TSC complex assembly and GAP activity on Rheb Nature Communications
author_facet	Huirong Yang Zishuo Yu Xizi Chen Jiabei Li Ningning Li Jiaxuan Cheng Ning Gao Hai-Xin Yuan Dan Ye Kun-Liang Guan Yanhui Xu
author_sort	Huirong Yang
title	Structural insights into TSC complex assembly and GAP activity on Rheb
title_short	Structural insights into TSC complex assembly and GAP activity on Rheb
title_full	Structural insights into TSC complex assembly and GAP activity on Rheb
title_fullStr	Structural insights into TSC complex assembly and GAP activity on Rheb
title_full_unstemmed	Structural insights into TSC complex assembly and GAP activity on Rheb
title_sort	structural insights into tsc complex assembly and gap activity on rheb
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.
url	https://doi.org/10.1038/s41467-020-20522-4
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Structural insights into TSC complex assembly and GAP activity on Rheb

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