Correlation of peripheral blood regulatory T cell content with inflammatory stress response and immune response in children with both pneumonia and sepsis

• Main Authors: Yuan He, Hai-Ying Yi, Shu-Jie Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-04-01
• Series: Journal of Hainan Medical University
• Subjects: Sepsis; Pneumonia; Regulatory T cell; Inflammatory response; Oxidative stress; Immunoglobulin
• Online Access: http://www.hnykdxxb.com/PDF/201804/26.pdf

Objective: To investigate the correlation of peripheral blood regulatory T cell content with inflammatory stress response and immune response in children with both pneumonia and sepsis. Methods: A total of 90 child patient with both pneumonia and sepsis who were treated in our hospital between September 2014 and April 2017 were selected as sepsis group and 100 healthy children who received vaccination in our hospital during the same period were selected as normal control group. The differences in peripheral blood regulatory T cell (Treg) expression as well as serum inflammatory mediator, oxidative stress index and immunoglobulin contents were compared between the two groups of children. Pearson test was used to evaluate the correlation between Treg expression and disease in patients with both pneumonia and sepsis. Results: Peripheral blood Treg expression of sepsis group was significantly higher than that of control group; serum inflammatory mediators PCT, hs-CRP, TNF-α and IL-6 contents were higher than those of control group; serum oxidative stress indexes―nitric oxide and malondialdehyde contents were higher than those of control group whereas superoxide dismutase content was lower than that of control group; immunoglobulin IgA, IgM and IgG contents were lower than those of normal control group. Pearson test showed that peripheral blood Treg expression of children with both pneumonia and sepsis was directly correlated with the inflammatory stress response and immune response. Conclusion: Peripheral blood Treg expression significantly increases in children with both pneumonia and sepsis, which could directly affect the inflammatory stress response extent and humoral immune function.