Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency

Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency

Abstract Objective Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency in Western countries. Patients can suffer from recurrent infections and autoimmune diseases because of a largely unknown aetiology. To increase insights into the pathophysiology of the disease, we studied...

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Main Authors: Christina Grosserichter‐Wagener, Alexander Franco‐Gallego, Fatemeh Ahmadi, Marcela Moncada‐Vélez, Virgil ASH Dalm, Jessica Lineth Rojas, Julio César Orrego, Natalia Correa Vargas, Lennart Hammarström, Marco WJ Schreurs, Willem A Dik, P Martin vanHagen, Louis Boon, Jacques JM vanDongen, Mirjam van derBurg, Qiang Pan‐Hammarström, José L Franco, Menno C vanZelm
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
B‐cell memory
cytokine concentration
IgA
selective IgA deficiency
Th1 cells
Th17 cells
Online Access:https://doi.org/10.1002/cti2.1130

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