Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Per...
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
2016-01-01
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doaj-d749ac0516ae4a68b86837fbe925388b2020-11-24T21:06:36ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública1678-44642016-01-0132110.1590/0102-311X00095815S0102-311X2016000100601Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary resultsCynthia BragaMaria de Fátima Pessoa Militão de AlbuquerqueMarli Tenório CordeiroPriscila M. S. CastanhaAnita RameshNeal AlexanderMaria Júlia G. de MelloErnesto T. A. Marques JrCelina M. Turchi MartelliAbstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601&lng=en&tlng=enInmunización PasivaDengueEstudios de Cohortes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cynthia Braga Maria de Fátima Pessoa Militão de Albuquerque Marli Tenório Cordeiro Priscila M. S. Castanha Anita Ramesh Neal Alexander Maria Júlia G. de Mello Ernesto T. A. Marques Jr Celina M. Turchi Martelli |
spellingShingle |
Cynthia Braga Maria de Fátima Pessoa Militão de Albuquerque Marli Tenório Cordeiro Priscila M. S. Castanha Anita Ramesh Neal Alexander Maria Júlia G. de Mello Ernesto T. A. Marques Jr Celina M. Turchi Martelli Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results Cadernos de Saúde Pública Inmunización Pasiva Dengue Estudios de Cohortes |
author_facet |
Cynthia Braga Maria de Fátima Pessoa Militão de Albuquerque Marli Tenório Cordeiro Priscila M. S. Castanha Anita Ramesh Neal Alexander Maria Júlia G. de Mello Ernesto T. A. Marques Jr Celina M. Turchi Martelli |
author_sort |
Cynthia Braga |
title |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
title_short |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
title_full |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
title_fullStr |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
title_full_unstemmed |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
title_sort |
prospective birth cohort in a hyperendemic dengue area in northeast brazil: methods and preliminary results |
publisher |
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
series |
Cadernos de Saúde Pública |
issn |
1678-4464 |
publishDate |
2016-01-01 |
description |
Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis. |
topic |
Inmunización Pasiva Dengue Estudios de Cohortes |
url |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601&lng=en&tlng=en |
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