The Impact of the Cancer Microenvironment on Macrophage Phenotypes
Within the tumor microenvironment, there is an intricate communication happening between tumor and stromal cells. This information exchange, in the form of cytokines, growth factors, extracellular vesicles, danger molecules, cell debris, and other factors, is capable of modulating the function of im...
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doaj-d749e8afe804433b8b67f112bc052dcf2020-11-25T02:31:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-06-011110.3389/fimmu.2020.01308534832The Impact of the Cancer Microenvironment on Macrophage PhenotypesSunyoung Ham0Sunyoung Ham1Luize G. Lima2Erica Lek3Andreas Möller4Andreas Möller5Tumor Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaFaculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, AustraliaTumor Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaTumor Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaTumor Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaFaculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, AustraliaWithin the tumor microenvironment, there is an intricate communication happening between tumor and stromal cells. This information exchange, in the form of cytokines, growth factors, extracellular vesicles, danger molecules, cell debris, and other factors, is capable of modulating the function of immune cells. The triggering of specific responses, including phenotypic alterations, can ultimately result in either immune surveillance or tumor cell survival. Macrophages are a well-studied cell lineage illustrating the different cellular phenotypes possible, depending on the tumor microenvironmental context. While our understanding of macrophage responses is well documented in vitro, surprisingly, little work has been done to confirm these observations in the cancer microenvironment. In fact, there are examples of opposing reactions of macrophages to cytokines in cell culture and in vivo tumor settings. Additionally, it seems that different macrophage lineages, for example tissue-resident and monocyte-derived macrophages, respond differently to cytokines and other cancer-derived signals. In this review article, we will describe and discuss the diverging reports on how cancer cells influence monocyte-derived and tissue-resident macrophage traits in vivo.https://www.frontiersin.org/article/10.3389/fimmu.2020.01308/fulltumor microenvironmenttissue-resident macrophagemonocyte-derived macrophagesmall extracellular vesiclestumor-derived cytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sunyoung Ham Sunyoung Ham Luize G. Lima Erica Lek Andreas Möller Andreas Möller |
spellingShingle |
Sunyoung Ham Sunyoung Ham Luize G. Lima Erica Lek Andreas Möller Andreas Möller The Impact of the Cancer Microenvironment on Macrophage Phenotypes Frontiers in Immunology tumor microenvironment tissue-resident macrophage monocyte-derived macrophage small extracellular vesicles tumor-derived cytokines |
author_facet |
Sunyoung Ham Sunyoung Ham Luize G. Lima Erica Lek Andreas Möller Andreas Möller |
author_sort |
Sunyoung Ham |
title |
The Impact of the Cancer Microenvironment on Macrophage Phenotypes |
title_short |
The Impact of the Cancer Microenvironment on Macrophage Phenotypes |
title_full |
The Impact of the Cancer Microenvironment on Macrophage Phenotypes |
title_fullStr |
The Impact of the Cancer Microenvironment on Macrophage Phenotypes |
title_full_unstemmed |
The Impact of the Cancer Microenvironment on Macrophage Phenotypes |
title_sort |
impact of the cancer microenvironment on macrophage phenotypes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-06-01 |
description |
Within the tumor microenvironment, there is an intricate communication happening between tumor and stromal cells. This information exchange, in the form of cytokines, growth factors, extracellular vesicles, danger molecules, cell debris, and other factors, is capable of modulating the function of immune cells. The triggering of specific responses, including phenotypic alterations, can ultimately result in either immune surveillance or tumor cell survival. Macrophages are a well-studied cell lineage illustrating the different cellular phenotypes possible, depending on the tumor microenvironmental context. While our understanding of macrophage responses is well documented in vitro, surprisingly, little work has been done to confirm these observations in the cancer microenvironment. In fact, there are examples of opposing reactions of macrophages to cytokines in cell culture and in vivo tumor settings. Additionally, it seems that different macrophage lineages, for example tissue-resident and monocyte-derived macrophages, respond differently to cytokines and other cancer-derived signals. In this review article, we will describe and discuss the diverging reports on how cancer cells influence monocyte-derived and tissue-resident macrophage traits in vivo. |
topic |
tumor microenvironment tissue-resident macrophage monocyte-derived macrophage small extracellular vesicles tumor-derived cytokines |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01308/full |
work_keys_str_mv |
AT sunyoungham theimpactofthecancermicroenvironmentonmacrophagephenotypes AT sunyoungham theimpactofthecancermicroenvironmentonmacrophagephenotypes AT luizeglima theimpactofthecancermicroenvironmentonmacrophagephenotypes AT ericalek theimpactofthecancermicroenvironmentonmacrophagephenotypes AT andreasmoller theimpactofthecancermicroenvironmentonmacrophagephenotypes AT andreasmoller theimpactofthecancermicroenvironmentonmacrophagephenotypes AT sunyoungham impactofthecancermicroenvironmentonmacrophagephenotypes AT sunyoungham impactofthecancermicroenvironmentonmacrophagephenotypes AT luizeglima impactofthecancermicroenvironmentonmacrophagephenotypes AT ericalek impactofthecancermicroenvironmentonmacrophagephenotypes AT andreasmoller impactofthecancermicroenvironmentonmacrophagephenotypes AT andreasmoller impactofthecancermicroenvironmentonmacrophagephenotypes |
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