Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues.

Proteins are used as prognostic and predictive biomarkers in breast cancer. However, the variability of protein expression within the same tumor is not well studied. The aim of this study was to assess intratumoral heterogeneity in protein expression levels by reverse-phase-protein-arrays (RPPA) (i)...

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Bibliographic Details
Main Authors: Katharina Malinowsky, Mithu Raychaudhuri, Theresa Buchner, Sabrina Thulke, Claudia Wolff, Heinz Höfler, Karl-Friedrich Becker, Stefanie Avril
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3390380?pdf=render