Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus

Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus

<p>Abstract</p> <p>Background</p> <p>Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality.</p> <p>Methods</p> <p>We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in...

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Main Authors: Qualls Clifford R, Sharrar Janeen, Flores Ranee A, Chavez Robert S, Caprihan Arvind, Jung Rex E, Sibbitt Wilmer, Roldan Carlos A
Format: Article
Language:English
Published: BMC 2010-07-01
Series:BMC Neurology
Online Access:http://www.biomedcentral.com/1471-2377/10/65
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spelling doaj-d76101a8cd144a0584f57e9b99ff70ac2020-11-25T00:15:22ZengBMCBMC Neurology1471-23772010-07-011016510.1186/1471-2377-10-65Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosusQualls Clifford RSharrar JaneenFlores Ranee AChavez Robert SCaprihan ArvindJung Rex ESibbitt WilmerRoldan Carlos A<p>Abstract</p> <p>Background</p> <p>Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality.</p> <p>Methods</p> <p>We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls.</p> <p>Results</p> <p>NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata.</p> <p>Conclusions</p> <p>Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.</p> http://www.biomedcentral.com/1471-2377/10/65
collection DOAJ
language English
format Article
sources DOAJ
author Qualls Clifford R
Sharrar Janeen
Flores Ranee A
Chavez Robert S
Caprihan Arvind
Jung Rex E
Sibbitt Wilmer
Roldan Carlos A
spellingShingle Qualls Clifford R
Sharrar Janeen
Flores Ranee A
Chavez Robert S
Caprihan Arvind
Jung Rex E
Sibbitt Wilmer
Roldan Carlos A
Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
BMC Neurology
author_facet Qualls Clifford R
Sharrar Janeen
Flores Ranee A
Chavez Robert S
Caprihan Arvind
Jung Rex E
Sibbitt Wilmer
Roldan Carlos A
author_sort Qualls Clifford R
title Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
title_short Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
title_full Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
title_fullStr Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
title_full_unstemmed Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
title_sort diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
publisher BMC
series BMC Neurology
issn 1471-2377
publishDate 2010-07-01
description <p>Abstract</p> <p>Background</p> <p>Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality.</p> <p>Methods</p> <p>We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls.</p> <p>Results</p> <p>NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata.</p> <p>Conclusions</p> <p>Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.</p>
url http://www.biomedcentral.com/1471-2377/10/65
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AT sharrarjaneen diffusiontensorimaginginneuropsychiatricsystemiclupuserythematosus
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AT caprihanarvind diffusiontensorimaginginneuropsychiatricsystemiclupuserythematosus
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AT roldancarlosa diffusiontensorimaginginneuropsychiatricsystemiclupuserythematosus
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