Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials
<b> </b>The present study reports on the encapsulation of <i>Elsholtzia ciliata</i> ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsu...
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doaj-d761d456233042cc9f8bbb463629fb2b2020-11-25T03:00:27ZengMDPI AGMolecules1420-30492020-05-01252237223710.3390/molecules25092237Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating MaterialsLauryna Pudziuvelyte0Mindaugas Marksa1Katarzyna Sosnowska2Katarzyna Winnicka3Ramune Morkuniene4Jurga Bernatoniene5Institute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, LithuaniaDepartment of Analytical and Toxicological Chemistry, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, LithuaniaDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15222 Białystok, PolandDepartment of Drug Chemistry, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, LithuaniaInstitute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, Lithuania<b> </b>The present study reports on the encapsulation of <i>Elsholtzia ciliata</i> ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsulants. The encapsulation ability of the final mixtures was evaluated based on their microencapsulating efficiency (EE) of total phenolic compounds (TPC) and the physicochemical properties of freeze-dried powders. Results showed that the freeze-dried powders produced using two encapsulants have a lower moisture content, but higher solubility, Carr index, and Hausner ratio than freeze-dried powders produced using only one encapsulant in the formulation. The microencapsulating efficiency of TPC also varied depending on encapsulants used. The lowest EE% of TPC was determined with maltodextrin (21.17%), and the highest with sodium caseinate (83.02%). Scanning electron microscopy revealed that freeze-drying resulted in the formation of different size, irregular shape glassy particles. This study demonstrated good mucoadhesive properties of freeze-dried powders, which could be incorporated in buccal or oral delivery dosage forms. In conclusion, the microencapsulation of <i>E. ciliata</i> ethanolic extract by freeze-drying is an effective method to produce new value-added pharmaceutical or food formulations with polyphenols.https://www.mdpi.com/1420-3049/25/9/2237Elsholtzia ciliataethanolic extractessential oilfreeze-dryingpolyphenolsmucoadhesive properties |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lauryna Pudziuvelyte Mindaugas Marksa Katarzyna Sosnowska Katarzyna Winnicka Ramune Morkuniene Jurga Bernatoniene |
spellingShingle |
Lauryna Pudziuvelyte Mindaugas Marksa Katarzyna Sosnowska Katarzyna Winnicka Ramune Morkuniene Jurga Bernatoniene Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials Molecules Elsholtzia ciliata ethanolic extract essential oil freeze-drying polyphenols mucoadhesive properties |
author_facet |
Lauryna Pudziuvelyte Mindaugas Marksa Katarzyna Sosnowska Katarzyna Winnicka Ramune Morkuniene Jurga Bernatoniene |
author_sort |
Lauryna Pudziuvelyte |
title |
Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials |
title_short |
Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials |
title_full |
Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials |
title_fullStr |
Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials |
title_full_unstemmed |
Freeze-Drying Technique for Microencapsulation of <i>Elsholtzia ciliata</i> Ethanolic Extract Using Different Coating Materials |
title_sort |
freeze-drying technique for microencapsulation of <i>elsholtzia ciliata</i> ethanolic extract using different coating materials |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-05-01 |
description |
<b> </b>The present study reports on the encapsulation of <i>Elsholtzia ciliata</i> ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsulants. The encapsulation ability of the final mixtures was evaluated based on their microencapsulating efficiency (EE) of total phenolic compounds (TPC) and the physicochemical properties of freeze-dried powders. Results showed that the freeze-dried powders produced using two encapsulants have a lower moisture content, but higher solubility, Carr index, and Hausner ratio than freeze-dried powders produced using only one encapsulant in the formulation. The microencapsulating efficiency of TPC also varied depending on encapsulants used. The lowest EE% of TPC was determined with maltodextrin (21.17%), and the highest with sodium caseinate (83.02%). Scanning electron microscopy revealed that freeze-drying resulted in the formation of different size, irregular shape glassy particles. This study demonstrated good mucoadhesive properties of freeze-dried powders, which could be incorporated in buccal or oral delivery dosage forms. In conclusion, the microencapsulation of <i>E. ciliata</i> ethanolic extract by freeze-drying is an effective method to produce new value-added pharmaceutical or food formulations with polyphenols. |
topic |
Elsholtzia ciliata ethanolic extract essential oil freeze-drying polyphenols mucoadhesive properties |
url |
https://www.mdpi.com/1420-3049/25/9/2237 |
work_keys_str_mv |
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