Clinical efficacy and pharmacokinetics of colistimethate sodium and colistin in critically ill patients in an Indian hospital with high endemic rates of multidrug-resistant Gram-negative bacterial infections: A prospective observational study

Clinical efficacy and pharmacokinetics of colistimethate sodium and colistin in critically ill patients in an Indian hospital with high endemic rates of multidrug-resistant Gram-negative bacterial infections: A prospective observational study

Background: Safe and effective use of colistin requires robust pharmacokinetic (PK) and pharmacodynamic (PD) data to guide dosing. Aim: To evaluate the pharmacokinetics of colistimethate sodium and colistin in critically ill patients and correlate with clinical efficacy and renal function. Materials...

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Main Authors: Merlin Moni, A Sangita Sudhir, T.S. Dipu, Zubair Mohamed, Binny Pushpa Prabhu, Fabia Edathadathil, Sabarish Balachandran, Sanjeev K Singh, Preetha Prasanna, Veena P Menon, Twisha Patel, Payal Patel, Keith S Kaye, Vidya P Menon
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:International Journal of Infectious Diseases
Subjects:
Therapeutic drug monitoring
Pharmacokinetics
Colistimethate sodium
Colistin
Multidrug-resistant infections
Clinical efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S120197122030638X

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