IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells

IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells

Abstract Background Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors NF-κB. The intracellular Ca2+ ([Ca2+]i) signal is required for activatio...

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Bibliographic Details
Main Authors: Yu Xia, Peng-Cheng Cai, Fan Yu, Liang Xiong, Xin-Liang He, Shan-Shan Rao, Feng Chen, Xiang-Ping Yang, Wan-Li Ma, Hong Ye
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Respiratory Research
Subjects:
IL-4
Bronchial epithelial cells
Lipid rafts
Intracellular Ca2 + 
MUC5AC
Asthma
Online Access:http://link.springer.com/article/10.1186/s12931-017-0657-z

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