Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration.
c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration, while trihydrophobin 1 (TH1) inhibits MAPK/ERK activation and cell migration through interaction with A-Raf and PAK1 and inhibiting their kinase activities. Here we show that c-Src interacts with TH1 by GST-pull down assay,...
Main Authors: | Weibin Wu, Zhichao Sun, Jingwen Wu, Xiaomin Peng, Huacheng Gan, Chunyi Zhang, Lingling Ji, Jianhui Xie, Haiyan Zhu, Shifang Ren, Jianxin Gu, Songwen Zhang |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3253115?pdf=render |
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