Type I interferon sensing unlocks dormant adipocyte inflammatory potential

White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte phenotype.

Bibliographic Details
Main Authors:	Calvin C. Chan, Michelle S. M. A. Damen, Maria E. Moreno-Fernandez, Traci E. Stankiewicz, Monica Cappelletti, Pablo C. Alarcon, Jarren R. Oates, Jessica R. Doll, Rajib Mukherjee, Xiaoting Chen, Rebekah Karns, Matthew T. Weirauch, Michael A. Helmrath, Thomas H. Inge, Senad Divanovic
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16571-4

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spelling	doaj-d7769e000a41416a858c145b467956f72021-06-06T11:14:23ZengNature Publishing GroupNature Communications2041-17232020-06-0111111510.1038/s41467-020-16571-4Type I interferon sensing unlocks dormant adipocyte inflammatory potentialCalvin C. Chan0Michelle S. M. A. Damen1Maria E. Moreno-Fernandez2Traci E. Stankiewicz3Monica Cappelletti4Pablo C. Alarcon5Jarren R. Oates6Jessica R. Doll7Rajib Mukherjee8Xiaoting Chen9Rebekah Karns10Matthew T. Weirauch11Michael A. Helmrath12Thomas H. Inge13Senad Divanovic14Medical Scientist Training Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineMedical Scientist Training Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of MedicineImmunology Graduate Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineThe Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineDivision of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical CenterDepartment of Surgery, Children’s Hospital ColoradoMedical Scientist Training Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of MedicineWhite adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte phenotype.https://doi.org/10.1038/s41467-020-16571-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Calvin C. Chan Michelle S. M. A. Damen Maria E. Moreno-Fernandez Traci E. Stankiewicz Monica Cappelletti Pablo C. Alarcon Jarren R. Oates Jessica R. Doll Rajib Mukherjee Xiaoting Chen Rebekah Karns Matthew T. Weirauch Michael A. Helmrath Thomas H. Inge Senad Divanovic
spellingShingle	Calvin C. Chan Michelle S. M. A. Damen Maria E. Moreno-Fernandez Traci E. Stankiewicz Monica Cappelletti Pablo C. Alarcon Jarren R. Oates Jessica R. Doll Rajib Mukherjee Xiaoting Chen Rebekah Karns Matthew T. Weirauch Michael A. Helmrath Thomas H. Inge Senad Divanovic Type I interferon sensing unlocks dormant adipocyte inflammatory potential Nature Communications
author_facet	Calvin C. Chan Michelle S. M. A. Damen Maria E. Moreno-Fernandez Traci E. Stankiewicz Monica Cappelletti Pablo C. Alarcon Jarren R. Oates Jessica R. Doll Rajib Mukherjee Xiaoting Chen Rebekah Karns Matthew T. Weirauch Michael A. Helmrath Thomas H. Inge Senad Divanovic
author_sort	Calvin C. Chan
title	Type I interferon sensing unlocks dormant adipocyte inflammatory potential
title_short	Type I interferon sensing unlocks dormant adipocyte inflammatory potential
title_full	Type I interferon sensing unlocks dormant adipocyte inflammatory potential
title_fullStr	Type I interferon sensing unlocks dormant adipocyte inflammatory potential
title_full_unstemmed	Type I interferon sensing unlocks dormant adipocyte inflammatory potential
title_sort	type i interferon sensing unlocks dormant adipocyte inflammatory potential
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte phenotype.
url	https://doi.org/10.1038/s41467-020-16571-4
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Type I interferon sensing unlocks dormant adipocyte inflammatory potential

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