The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)

The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numero...

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Main Authors: Jacob S. Brenner, Raisa Yu. Kiseleva, Patrick M. Glassman, Hamideh Parhiz, Colin F. Greineder, Elizabeth D. Hood, Vladimir V. Shuvaev, Vladimir R. Muzykantov
Format: Article
Language:English
Published: SAGE Publishing 2018-01-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045893217752329
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spelling doaj-d779c2e5bddd44719f1c68186b72e8b12020-11-25T03:23:47ZengSAGE PublishingPulmonary Circulation2045-89402018-01-01810.1177/2045893217752329The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)Jacob S. BrennerRaisa Yu. KiselevaPatrick M. GlassmanHamideh ParhizColin F. GreinederElizabeth D. HoodVladimir V. ShuvaevVladimir R. MuzykantovThe pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk–benefit ratio and safety—parameters one should keep in mind when developing a translational therapeutic.https://doi.org/10.1177/2045893217752329
collection DOAJ
language English
format Article
sources DOAJ
author Jacob S. Brenner
Raisa Yu. Kiseleva
Patrick M. Glassman
Hamideh Parhiz
Colin F. Greineder
Elizabeth D. Hood
Vladimir V. Shuvaev
Vladimir R. Muzykantov
spellingShingle Jacob S. Brenner
Raisa Yu. Kiseleva
Patrick M. Glassman
Hamideh Parhiz
Colin F. Greineder
Elizabeth D. Hood
Vladimir V. Shuvaev
Vladimir R. Muzykantov
The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
Pulmonary Circulation
author_facet Jacob S. Brenner
Raisa Yu. Kiseleva
Patrick M. Glassman
Hamideh Parhiz
Colin F. Greineder
Elizabeth D. Hood
Vladimir V. Shuvaev
Vladimir R. Muzykantov
author_sort Jacob S. Brenner
title The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
title_short The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
title_full The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
title_fullStr The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
title_full_unstemmed The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
title_sort new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 grover conference series)
publisher SAGE Publishing
series Pulmonary Circulation
issn 2045-8940
publishDate 2018-01-01
description The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk–benefit ratio and safety—parameters one should keep in mind when developing a translational therapeutic.
url https://doi.org/10.1177/2045893217752329
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