CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy
The aim of this study is to evaluate the feasibility, safety, and clinical efficacy of CT-guided 125I seed interstitial brachytherapy in patients with recurrent spinal metastases after external beam radiotherapy (EBRT). Between August 2003 and September 2015, 26 spinal metastatic lesions (24 patient...
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doaj-d77eddd50b0c4e7aa05b6691440ac11d2020-11-25T01:34:35ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/82659078265907CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam RadiotherapyLihong Yao0Qianqian Cao1Junjie Wang2Jiwen Yang3Na Meng4Fuxin Guo5Yuliang Jiang6Suqing Tian7Haitao Sun8Department of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaCancer Center, The Second Hospital of Shandong University, Jinan, Shandong 250033, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Wannan Medical College, No. 2 Zhe Shan Xi Road, Jinghu District, Wuhu 241001, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaDepartment of Radiation Oncology, Peking University Third Hospital, Hua-Yuan North Road No. 49, Beijing 100191, ChinaThe aim of this study is to evaluate the feasibility, safety, and clinical efficacy of CT-guided 125I seed interstitial brachytherapy in patients with recurrent spinal metastases after external beam radiotherapy (EBRT). Between August 2003 and September 2015, 26 spinal metastatic lesions (24 patients) were reirradiated by this salvage therapy modality. Treatment for all patients was preplanned using a three-dimensional treatment planning system 3–5 days before 125I seed interstitial brachytherapy; dosimetry verification was performed immediately after seed implantation. Median actual D90 was 99 Gy (range, 90–176), and spinal cord median Dmax was 39 Gy (range, 6–110). Median local control (LC) was 12 months (95% CI: 7.0–17.0). The 6- and 12-month LC rates were 52% and 40%, respectively. Median overall survival (OS) was 11 months (95% CI: 7.7–14.3); 6-month and 1-, 2-, and 3-year OS rates were 65%, 37%, 14%, and 9%, respectively. Pain-free survival ranged from 2 to 42 months (median, 6; 95% CI: 4.6–7.4). Treatment was well-tolerated, with no radiation-induced vertebral compression fractures or myelopathy reported. Reirradiation with CT-guided 125I seed interstitial brachytherapy appears to be feasible, safe, and effective as pain relief or salvage treatment for patients with recurrent spinal metastases after EBRT.http://dx.doi.org/10.1155/2016/8265907 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lihong Yao Qianqian Cao Junjie Wang Jiwen Yang Na Meng Fuxin Guo Yuliang Jiang Suqing Tian Haitao Sun |
spellingShingle |
Lihong Yao Qianqian Cao Junjie Wang Jiwen Yang Na Meng Fuxin Guo Yuliang Jiang Suqing Tian Haitao Sun CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy BioMed Research International |
author_facet |
Lihong Yao Qianqian Cao Junjie Wang Jiwen Yang Na Meng Fuxin Guo Yuliang Jiang Suqing Tian Haitao Sun |
author_sort |
Lihong Yao |
title |
CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy |
title_short |
CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy |
title_full |
CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy |
title_fullStr |
CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy |
title_full_unstemmed |
CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy |
title_sort |
ct-guided 125i seed interstitial brachytherapy as a salvage treatment for recurrent spinal metastases after external beam radiotherapy |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
The aim of this study is to evaluate the feasibility, safety, and clinical efficacy of CT-guided 125I seed interstitial brachytherapy in patients with recurrent spinal metastases after external beam radiotherapy (EBRT). Between August 2003 and September 2015, 26 spinal metastatic lesions (24 patients) were reirradiated by this salvage therapy modality. Treatment for all patients was preplanned using a three-dimensional treatment planning system 3–5 days before 125I seed interstitial brachytherapy; dosimetry verification was performed immediately after seed implantation. Median actual D90 was 99 Gy (range, 90–176), and spinal cord median Dmax was 39 Gy (range, 6–110). Median local control (LC) was 12 months (95% CI: 7.0–17.0). The 6- and 12-month LC rates were 52% and 40%, respectively. Median overall survival (OS) was 11 months (95% CI: 7.7–14.3); 6-month and 1-, 2-, and 3-year OS rates were 65%, 37%, 14%, and 9%, respectively. Pain-free survival ranged from 2 to 42 months (median, 6; 95% CI: 4.6–7.4). Treatment was well-tolerated, with no radiation-induced vertebral compression fractures or myelopathy reported. Reirradiation with CT-guided 125I seed interstitial brachytherapy appears to be feasible, safe, and effective as pain relief or salvage treatment for patients with recurrent spinal metastases after EBRT. |
url |
http://dx.doi.org/10.1155/2016/8265907 |
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