A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging

A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging

<b>: </b>Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suff...

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Main Authors: Fouzi Mouffouk, Hacene Serrai, Sourav Bhaduri, Rik Achten, Mozhdeh Seyyedhamzeh, Ali A. Husain, Abdullah Alhendal, Mohammed Zourob
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
cancer imaging
mri
ph
sensors
Online Access:https://www.mdpi.com/1420-3049/25/7/1513
id doaj-d781a368e4ce4914ac6056794954eb76
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spelling doaj-d781a368e4ce4914ac6056794954eb762020-11-25T00:44:43ZengMDPI AGMolecules1420-30492020-03-01257151310.3390/molecules25071513molecules25071513A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance ImagingFouzi Mouffouk0Hacene Serrai1Sourav Bhaduri2Rik Achten3Mozhdeh Seyyedhamzeh4Ali A. Husain5Abdullah Alhendal6Mohammed Zourob7Department of Chemistry, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitDepartment of Diagnostic Sciences, University of Ghent, Gent 9000, BelgiumDepartment of Diagnostic Sciences, University of Ghent, Gent 9000, BelgiumDepartment of Diagnostic Sciences, University of Ghent, Gent 9000, BelgiumDepartment of Chemistry, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitDepartment of Chemistry, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitDepartment of Chemistry, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitDepartment of Chemistry, Alfaisal University, 12713 Riyadh, Saudi Arabia<b>: </b>Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability.https://www.mdpi.com/1420-3049/25/7/1513cancer imagingmriphsensors
collection DOAJ
language English
format Article
sources DOAJ
author Fouzi Mouffouk
Hacene Serrai
Sourav Bhaduri
Rik Achten
Mozhdeh Seyyedhamzeh
Ali A. Husain
Abdullah Alhendal
Mohammed Zourob
spellingShingle Fouzi Mouffouk
Hacene Serrai
Sourav Bhaduri
Rik Achten
Mozhdeh Seyyedhamzeh
Ali A. Husain
Abdullah Alhendal
Mohammed Zourob
A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
Molecules
cancer imaging
mri
ph
sensors
author_facet Fouzi Mouffouk
Hacene Serrai
Sourav Bhaduri
Rik Achten
Mozhdeh Seyyedhamzeh
Ali A. Husain
Abdullah Alhendal
Mohammed Zourob
author_sort Fouzi Mouffouk
title A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
title_short A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
title_full A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
title_fullStr A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
title_full_unstemmed A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
title_sort new class of smart gadolinium contrast agent for tissue ph probing using magnetic resonance imaging
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-03-01
description <b>: </b>Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability.
topic cancer imaging
mri
ph
sensors
url https://www.mdpi.com/1420-3049/25/7/1513
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