Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.
Pemetrexed is approved for first-line and maintenance treatment of patients with advanced or metastatic non-small-cell lung cancer (NSCLC). The protein kinase Akt/protein kinase B is a well-known regulator of cell survival which is activated by pemetrexed, but its role in pemetrexed-mediated cell de...
Main Authors: | Kun-Chieh Chen, Tsung-Ying Yang, Chun-Chi Wu, Chi-Chih Cheng, Shih-Lan Hsu, Hsiao-Wen Hung, Jian-Wei Chen, Gee-Chen Chang |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4029963?pdf=render |
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