Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study
(1) Background: Peripheral nerve involvement is increasingly recognized in Parkinson’s disease (PD). Although non-motor symptoms and postural instability are early features of atypical parkinsonian syndromes (APS), peripheral neuropathies in APS have not been addressed in detail thus far. Therefore,...
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doaj-d7889921e93c41b38dccca67161962d82021-07-23T13:32:45ZengMDPI AGBrain Sciences2076-34252021-06-011187987910.3390/brainsci11070879Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative StudyRachel Rohmann0Eva Kühn1Raphael Scherbaum2Lovis Hilker3Saskia Kools4Leonard Scholz5Katharina Müller6Sophie Huckemann7Christiane Schneider-Gold8Ralf Gold9Kalliopi Pitarokoili10Lars Tönges11Eun Hae Kwon12Department of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, GermanyDepartment of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, Germany(1) Background: Peripheral nerve involvement is increasingly recognized in Parkinson’s disease (PD). Although non-motor symptoms and postural instability are early features of atypical parkinsonian syndromes (APS), peripheral neuropathies in APS have not been addressed in detail thus far. Therefore, the aim of this study was to investigate the prevalence and characteristics of polyneuropathies (PNP) in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), as representative syndromes of APS. (2) Methods: In total, 8 MSA and 6 PSP patients were comprehensively analyzed regarding subjective, clinical (motor and non-motor) and paraclinical PNP features using nerve conduction studies and high resolution nerve ultrasounds (HRUS). (3) Results: A total of 87.5% of MSA and 66.7% of PSP patients complained of at least one neuropathic symptom, with electrophysiological confirmation of PNP in 50.0% of both, MSA and PSP patients. PNP symptom severity in PSP and motor nerve amplitude in MSA were associated with compromised motor function. Morphologic nerve examination by HRUS showed few alterations according to the axonal type of PNP. (4) Conclusions: The overall high PNP symptom burden may be partially credited to the significant prevalence of electrophysiologically diagnosed PNP, and impact motor aspects of APS. The findings of this exploratory study reinforce further investigations on a larger scale, in order to elucidate peripheral nerve involvement and the underlying pathophysiological mechanisms of APS.https://www.mdpi.com/2076-3425/11/7/879polyneuropathyatypical parkinsonian syndromesmultiple system atrophyprogressive supranuclear palsynerve conduction study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rachel Rohmann Eva Kühn Raphael Scherbaum Lovis Hilker Saskia Kools Leonard Scholz Katharina Müller Sophie Huckemann Christiane Schneider-Gold Ralf Gold Kalliopi Pitarokoili Lars Tönges Eun Hae Kwon |
spellingShingle |
Rachel Rohmann Eva Kühn Raphael Scherbaum Lovis Hilker Saskia Kools Leonard Scholz Katharina Müller Sophie Huckemann Christiane Schneider-Gold Ralf Gold Kalliopi Pitarokoili Lars Tönges Eun Hae Kwon Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study Brain Sciences polyneuropathy atypical parkinsonian syndromes multiple system atrophy progressive supranuclear palsy nerve conduction study |
author_facet |
Rachel Rohmann Eva Kühn Raphael Scherbaum Lovis Hilker Saskia Kools Leonard Scholz Katharina Müller Sophie Huckemann Christiane Schneider-Gold Ralf Gold Kalliopi Pitarokoili Lars Tönges Eun Hae Kwon |
author_sort |
Rachel Rohmann |
title |
Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study |
title_short |
Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study |
title_full |
Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study |
title_fullStr |
Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study |
title_full_unstemmed |
Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study |
title_sort |
prevalence and characteristics of polyneuropathy in atypical parkinsonian syndromes: an explorative study |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-06-01 |
description |
(1) Background: Peripheral nerve involvement is increasingly recognized in Parkinson’s disease (PD). Although non-motor symptoms and postural instability are early features of atypical parkinsonian syndromes (APS), peripheral neuropathies in APS have not been addressed in detail thus far. Therefore, the aim of this study was to investigate the prevalence and characteristics of polyneuropathies (PNP) in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), as representative syndromes of APS. (2) Methods: In total, 8 MSA and 6 PSP patients were comprehensively analyzed regarding subjective, clinical (motor and non-motor) and paraclinical PNP features using nerve conduction studies and high resolution nerve ultrasounds (HRUS). (3) Results: A total of 87.5% of MSA and 66.7% of PSP patients complained of at least one neuropathic symptom, with electrophysiological confirmation of PNP in 50.0% of both, MSA and PSP patients. PNP symptom severity in PSP and motor nerve amplitude in MSA were associated with compromised motor function. Morphologic nerve examination by HRUS showed few alterations according to the axonal type of PNP. (4) Conclusions: The overall high PNP symptom burden may be partially credited to the significant prevalence of electrophysiologically diagnosed PNP, and impact motor aspects of APS. The findings of this exploratory study reinforce further investigations on a larger scale, in order to elucidate peripheral nerve involvement and the underlying pathophysiological mechanisms of APS. |
topic |
polyneuropathy atypical parkinsonian syndromes multiple system atrophy progressive supranuclear palsy nerve conduction study |
url |
https://www.mdpi.com/2076-3425/11/7/879 |
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