Striatal Dopamine D2-Muscarinic Acetylcholine M1 Receptor–Receptor Interaction in a Model of Movement Disorders
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor control deficits, which is associated with the loss of striatal dopaminergic neurons from the substantia nigra. In parallel to dopaminergic denervation, there is an increase of acetylcholine within the striatum, resultin...
Main Authors: | René A. J. Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M. Massari, Víctor Fernández-Dueñas, Christophe P. Stove, Francisco Ciruela |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-03-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00194/full |
Similar Items
-
Dopaminergic-cholinergic imbalance in movement disorders: a role for the novel striatal dopamine D2- muscarinic acetylcholine M1 receptor heteromer
by: René A J. Crans, et al.
Published: (2021-01-01) -
PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders
by: Fabiana Núñez, et al.
Published: (2018-10-01) -
Pridopidine Reverses Phencyclidine-Induced Memory Impairment
by: Kristoffer Sahlholm, et al.
Published: (2018-04-01) -
Adenosine A2A-dopamine D2 receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics
by: Víctor Fernandez-Duenas, et al.
Published: (2018-01-01) -
Atividade fungistÃtica de uma quitinase recombinante do feijÃo de corda [Vigna unguiculata (L.) (Walp.)] contra Lasiodiplodia theobromae Pat. (Griff. e Maubl.), agente causal da resinose do cajueiro (Anacardium occidentale L.)
by: AntÃnio Viana Lopes Neto
Published: (2014)