Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellula...

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Main Authors: Guolin Ma, Lian He, Shuzhong Liu, Jiansheng Xie, Zixian Huang, Ji Jing, Yi-Tsang Lee, Rui Wang, Hesheng Luo, Weidong Han, Yun Huang, Yubin Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14841-9
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spelling doaj-d794e4ce185f4e5981a7283cbeabcec02021-05-11T08:22:04ZengNature Publishing GroupNature Communications2041-17232020-02-0111111510.1038/s41467-020-14841-9Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signalingGuolin Ma0Lian He1Shuzhong Liu2Jiansheng Xie3Zixian Huang4Ji Jing5Yi-Tsang Lee6Rui Wang7Hesheng Luo8Weidong Han9Yun Huang10Yubin Zhou11Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityDepartment of Gastroenterology, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan UniversityDepartment of Medical Oncology, Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityCenter for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M UniversityCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M UniversityOptogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellular events.https://doi.org/10.1038/s41467-020-14841-9
collection DOAJ
language English
format Article
sources DOAJ
author Guolin Ma
Lian He
Shuzhong Liu
Jiansheng Xie
Zixian Huang
Ji Jing
Yi-Tsang Lee
Rui Wang
Hesheng Luo
Weidong Han
Yun Huang
Yubin Zhou
spellingShingle Guolin Ma
Lian He
Shuzhong Liu
Jiansheng Xie
Zixian Huang
Ji Jing
Yi-Tsang Lee
Rui Wang
Hesheng Luo
Weidong Han
Yun Huang
Yubin Zhou
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
Nature Communications
author_facet Guolin Ma
Lian He
Shuzhong Liu
Jiansheng Xie
Zixian Huang
Ji Jing
Yi-Tsang Lee
Rui Wang
Hesheng Luo
Weidong Han
Yun Huang
Yubin Zhou
author_sort Guolin Ma
title Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_short Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_full Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_fullStr Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_full_unstemmed Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_sort optogenetic engineering to probe the molecular choreography of stim1-mediated cell signaling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-02-01
description Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellular events.
url https://doi.org/10.1038/s41467-020-14841-9
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